BRD-K99252563_QL-XII-47_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K99252563_QL-XII-47_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
AZU1 azurocidin 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTGF connective tissue growth factor
DNMBP dynamin binding protein
DOK5 docking protein 5
DSP desmoplakin
EDN1 endothelin 1
EFNA1 ephrin-A1
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLG filaggrin
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LIPG lipase, endothelial
LOR loricrin
MPO myeloperoxidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRTN3 proteinase 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RDX radixin
RGCC regulator of cell cycle
SNX13 sorting nexin 13
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AGTR1 angiotensin II receptor, type 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
BASP1 brain abundant, membrane attached signal protein 1
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CLDN7 claudin 7
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FOLR1 folate receptor 1 (adult)
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GLUL glutamate-ammonia ligase
GREB1 growth regulation by estrogen in breast cancer 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
KAZN kazrin, periplakin interacting protein
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LEF1 lymphoid enhancer-binding factor 1
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCKSL1 MARCKS-like 1
MLPH melanophilin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID2 nidogen 2 (osteonidogen)
NPY1R neuropeptide Y receptor Y1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRUNE2 prune homolog 2 (Drosophila)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RBP1 retinol binding protein 1, cellular
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX11 SRY (sex determining region Y)-box 11
SPP1 secreted phosphoprotein 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TMEM158 transmembrane protein 158 (gene/pseudogene)
XYLT1 xylosyltransferase I