BRD-K99252563_QL-XII-47_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

306 genes differentially expressed following the BRD-K99252563_QL-XII-47_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ADGRG2 adhesion G protein-coupled receptor G2
AGFG1 ArfGAP with FG repeats 1
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATG101 autophagy related 101
BIRC2 baculoviral IAP repeat containing 2
BMP2 bone morphogenetic protein 2
BRD2 bromodomain containing 2
BTG3 BTG family, member 3
CCND1 cyclin D1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDK6 cyclin-dependent kinase 6
CGRRF1 cell growth regulator with ring finger domain 1
CLDN3 claudin 3
CLGN calmegin
COBL cordon-bleu WH2 repeat protein
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP1 cellular retinoic acid binding protein 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSNK1A1 casein kinase 1, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLX2 distal-less homeobox 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EPCAM epithelial cell adhesion molecule
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBXO11 F-box protein 11
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGF13 fibroblast growth factor 13
FGF2 fibroblast growth factor 2 (basic)
FGL1 fibrinogen-like 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FNTA farnesyltransferase, CAAX box, alpha
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALE UDP-galactose-4-epimerase
GLS glutaminase
GMFB glia maturation factor, beta
GOLGA8A golgin A8 family, member A
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KCMF1 potassium channel modulatory factor 1
KCTD5 potassium channel tetramerization domain containing 5
KDM5B lysine (K)-specific demethylase 5B
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT17 keratin 17, type I
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LHFPL2 lipoma HMGIC fusion partner-like 2
LIF leukemia inhibitory factor
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MED13 mediator complex subunit 13
MIR22HG MIR22 host gene
NBPF10 neuroblastoma breakpoint family, member 10
NCF2 neutrophil cytosolic factor 2
NOL7 nucleolar protein 7, 27kDa
NOTCH2NL notch 2 N-terminal like
NRG1 neuregulin 1
PAEP progestagen-associated endometrial protein
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTBP2 polypyrimidine tract binding protein 2
QKI QKI, KH domain containing, RNA binding
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RBM34 RNA binding motif protein 34
RBM47 RNA binding motif protein 47
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB2 SATB homeobox 2
SCG5 secretogranin V
SCGB2A2 secretoglobin, family 2A, member 2
SEC61G Sec61 gamma subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIRT1 sirtuin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX11 sorting nexin 11
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBL2 transducin (beta)-like 2
TFE3 transcription factor binding to IGHM enhancer 3
TGIF1 TGFB-induced factor homeobox 1
TMPRSS3 transmembrane protease, serine 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNPO1 transportin 1
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
TYMP thymidine phosphorylase
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VEGFA vascular endothelial growth factor A
WDR43 WD repeat domain 43
XBP1 X-box binding protein 1
YTHDC1 YTH domain containing 1
ZCCHC6 zinc finger, CCHC domain containing 6
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM10 ADAM metallopeptidase domain 10
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADI1 acireductone dioxygenase 1
AEBP1 AE binding protein 1
AHCY adenosylhomocysteinase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BGN biglycan
C7 complement component 7
CALD1 caldesmon 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALR calreticulin
CANT1 calcium activated nucleotidase 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNG1 cyclin G1
CD200 CD200 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CETN2 centrin, EF-hand protein, 2
CFH complement factor H
CFI complement factor I
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL6A3 collagen, type VI, alpha 3
CRELD2 cysteine-rich with EGF-like domains 2
CRTAP cartilage associated protein
CST3 cystatin C
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DHCR7 7-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLUD1 glutamate dehydrogenase 1
GLUD2 glutamate dehydrogenase 2
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GYPC glycophorin C (Gerbich blood group)
HADH hydroxyacyl-CoA dehydrogenase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
HOXB2 homeobox B2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HTRA1 HtrA serine peptidase 1
IFI16 interferon, gamma-inducible protein 16
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ISYNA1 inositol-3-phosphate synthase 1
KAZN kazrin, periplakin interacting protein
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL1 lysyl oxidase-like 1
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MAGED1 melanoma antigen family D1
MAN1C1 mannosidase, alpha, class 1C, member 1
MANSC1 MANSC domain containing 1
MCAM melanoma cell adhesion molecule
METTL7A methyltransferase like 7A
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGP matrix Gla protein
MPZL2 myelin protein zero-like 2
MSMO1 methylsterol monooxygenase 1
MTMR4 myotubularin related protein 4
MYCBP MYC binding protein
NAP1L1 nucleosome assembly protein 1-like 1
NCAPG2 non-SMC condensin II complex, subunit G2
NDN necdin, melanoma antigen (MAGE) family member
NNMT nicotinamide N-methyltransferase
NT5DC2 5'-nucleotidase domain containing 2
PAM peptidylglycine alpha-amidating monooxygenase
PARP1 poly (ADP-ribose) polymerase 1
PBX1 pre-B-cell leukemia homeobox 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDCD6 programmed cell death 6
PDIA4 protein disulfide isomerase family A, member 4
PHGDH phosphoglycerate dehydrogenase
PLTP phospholipid transfer protein
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
PSIP1 PC4 and SFRS1 interacting protein 1
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTGIS prostaglandin I2 (prostacyclin) synthase
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RBPMS RNA binding protein with multiple splicing
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RPA1 replication protein A1, 70kDa
RPA3 replication protein A3, 14kDa
RPN2 ribophorin II
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SRGN serglycin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STMN1 stathmin 1
SULF1 sulfatase 1
TBC1D16 TBC1 domain family, member 16
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMELESS timeless circadian clock
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TSPYL4 TSPY-like 4
TUBB tubulin, beta class I
VCAM1 vascular cell adhesion molecule 1