BRD-K99252563_QL-XII-47_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

331 genes differentially expressed following the BRD-K99252563_QL-XII-47_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AHNAK2 AHNAK nucleoprotein 2
AKR1C3 aldo-keto reductase family 1, member C3
AMOTL2 angiomotin like 2
ANG angiogenin, ribonuclease, RNase A family, 5
ANKRD12 ankyrin repeat domain 12
ANXA1 annexin A1
ANXA5 annexin A5
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARL8B ADP-ribosylation factor-like 8B
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK12 cyclin-dependent kinase 12
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLK4 CDC-like kinase 4
CLU clusterin
CRBN cereblon
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DCP1A decapping mRNA 1A
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EAPP E2F-associated phosphoprotein
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMC3 ER membrane protein complex subunit 3
EPCAM epithelial cell adhesion molecule
FEM1C fem-1 homolog c (C. elegans)
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FXYD3 FXYD domain containing ion transport regulator 3
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GTF2B general transcription factor IIB
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JMJD1C jumonji domain containing 1C
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KDM5B lysine (K)-specific demethylase 5B
KDSR 3-ketodihydrosphingosine reductase
KEAP1 kelch-like ECH-associated protein 1
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MMP3 matrix metallopeptidase 3
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA2 nuclear receptor coactivator 2
NEFL neurofilament, light polypeptide
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFE2L2 nuclear factor, erythroid 2-like 2
NGDN neuroguidin, EIF4E binding protein
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRBF2 nuclear receptor binding factor 2
NUPL1 nucleoporin like 1
OSER1 oxidative stress responsive serine-rich 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDLIM4 PDZ and LIM domain 4
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PER2 period circadian clock 2
PHF20L1 PHD finger protein 20-like 1
PHF3 PHD finger protein 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLIN2 perilipin 2
POLI polymerase (DNA directed) iota
PPAP2B phosphatidic acid phosphatase type 2B
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
QPCT glutaminyl-peptide cyclotransferase
RBM15 RNA binding motif protein 15
RBM34 RNA binding motif protein 34
RCOR3 REST corepressor 3
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNASE4 ribonuclease, RNase A family, 4
RNMT RNA (guanine-7-) methyltransferase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SDC4 syndecan 4
SEC62 SEC62 homolog (S. cerevisiae)
SIK3 SIK family kinase 3
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNX11 sorting nexin 11
SOCS2 suppressor of cytokine signaling 2
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRRM2 serine/arginine repetitive matrix 2
STK26 serine/threonine protein kinase 26
STK38L serine/threonine kinase 38 like
TBC1D15 TBC1 domain family, member 15
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TERF2IP telomeric repeat binding factor 2, interacting protein
TGIF1 TGFB-induced factor homeobox 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSG101 tumor susceptibility 101
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
YTHDC1 YTH domain containing 1
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC6 zinc finger, CCHC domain containing 6
ZMYM2 zinc finger, MYM-type 2
ZNF24 zinc finger protein 24
ZNF274 zinc finger protein 274
ZNF451 zinc finger protein 451
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADA adenosine deaminase
ADAM10 ADAM metallopeptidase domain 10
ALCAM activated leukocyte cell adhesion molecule
ARL4C ADP-ribosylation factor-like 4C
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AURKA aurora kinase A
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
C14ORF132 chromosome 14 open reading frame 132
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALU calumenin
CBX1 chromobox homolog 1
CCNA2 cyclin A2
CCNG1 cyclin G1
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLIC4 chloride intracellular channel 4
CTSZ cathepsin Z
CXCL12 chemokine (C-X-C motif) ligand 12
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPYSL2 dihydropyrimidinase-like 2
EMP2 epithelial membrane protein 2
ENO1 enolase 1, (alpha)
FHL1 four and a half LIM domains 1
GLDC glycine dehydrogenase (decarboxylating)
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GTSE1 G-2 and S-phase expressed 1
HADH hydroxyacyl-CoA dehydrogenase
HMG20B high mobility group 20B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGSF3 immunoglobulin superfamily, member 3
ISYNA1 inositol-3-phosphate synthase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB1 lamin B1
LMNB2 lamin B2
LYPLA1 lysophospholipase I
MAL mal, T-cell differentiation protein
MAOB monoamine oxidase B
MAT2A methionine adenosyltransferase II, alpha
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCAM melanoma cell adhesion molecule
MEIS2 Meis homeobox 2
MOB1A MOB kinase activator 1A
MPRIP myosin phosphatase Rho interacting protein
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
NCAPG2 non-SMC condensin II complex, subunit G2
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NEK2 NIMA-related kinase 2
NES nestin
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NXN nucleoredoxin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PDIA4 protein disulfide isomerase family A, member 4
PHGDH phosphoglycerate dehydrogenase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK1 polo-like kinase 1
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCD protein kinase C, delta
PRMT2 protein arginine methyltransferase 2
PSAT1 phosphoserine aminotransferase 1
PSCA prostate stem cell antigen
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
RAP2A RAP2A, member of RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SEPT11 septin 11
SEPW1 selenoprotein W, 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC2A4RG SLC2A4 regulator
SLN sarcolipin
SMC1A structural maintenance of chromosomes 1A
SMC4 structural maintenance of chromosomes 4
STMN1 stathmin 1
STS steroid sulfatase (microsomal), isozyme S
TARBP1 TAR (HIV-1) RNA binding protein 1
TFDP1 transcription factor Dp-1
TIMELESS timeless circadian clock
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TRAK2 trafficking protein, kinesin binding 2
TRIP13 thyroid hormone receptor interactor 13
TTC3 tetratricopeptide repeat domain 3
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
TWF2 twinfilin actin binding protein 2
TYMS thymidylate synthetase
UBE2J1 ubiquitin-conjugating enzyme E2, J1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta