BRD-K99252563_QL-XII-47_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K99252563_QL-XII-47_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BRD2 bromodomain containing 2
C6ORF48 chromosome 6 open reading frame 48
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHD1 chromodomain helicase DNA binding protein 1
CLK4 CDC-like kinase 4
COMP cartilage oligomeric matrix protein
CRY1 cryptochrome circadian clock 1
CTH cystathionine gamma-lyase
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DICER1 dicer 1, ribonuclease type III
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
EGR3 early growth response 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCMR Fc fragment of IgM receptor
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GPER1 G protein-coupled estrogen receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
ISG20 interferon stimulated exonuclease gene 20kDa
IVNS1ABP influenza virus NS1A binding protein
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NPC1 Niemann-Pick disease, type C1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
PDGFA platelet-derived growth factor alpha polypeptide
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAB9A RAB9A, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCYL3 SCY1-like 3 (S. cerevisiae)
SDCBP syndecan binding protein (syntenin)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNPO1 transportin 1
TRA2A transformer 2 alpha homolog (Drosophila)
TUFT1 tuftelin 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZNF410 zinc finger protein 410

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
B3GNT1
BEX1 brain expressed, X-linked 1
C1GALT1C1 C1GALT1-specific chaperone 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CDK14 cyclin-dependent kinase 14
CFI complement factor I
COL5A2 collagen, type V, alpha 2
CTSC cathepsin C
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1 dynamin 1
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHA3 EPH receptor A3
F2R coagulation factor II (thrombin) receptor
FAM3C family with sequence similarity 3, member C
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
GOLM1 golgi membrane protein 1
GPM6A glycoprotein M6A
HMGB3 high mobility group box 3
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KIF20A kinesin family member 20A
LIPA lipase A, lysosomal acid, cholesterol esterase
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
MAP3K5 mitogen-activated protein kinase kinase kinase 5
NEBL nebulette
NES nestin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F1 nuclear receptor subfamily 2, group F, member 1
OLFM4 olfactomedin 4
PAM peptidylglycine alpha-amidating monooxygenase
PBX1 pre-B-cell leukemia homeobox 1
PEBP1 phosphatidylethanolamine binding protein 1
PFN2 profilin 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPARG peroxisome proliferator-activated receptor gamma
PSIP1 PC4 and SFRS1 interacting protein 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RPS11 ribosomal protein S11
SCARB2 scavenger receptor class B, member 2
SEPP1 selenoprotein P, plasma, 1
SLC2A4RG SLC2A4 regulator
SMAD3 SMAD family member 3
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCEA2 transcription elongation factor A (SII), 2
TM4SF1 transmembrane 4 L six family member 1
TMEM100 transmembrane protein 100
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1