BRD-K98834634_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K98834634_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
APOD apolipoprotein D
ASPH aspartate beta-hydroxylase
BTG1 B-cell translocation gene 1, anti-proliferative
C1QB complement component 1, q subcomponent, B chain
C1RL complement component 1, r subcomponent-like
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CFD complement factor D (adipsin)
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CTSL cathepsin L
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK3 dickkopf WNT signaling pathway inhibitor 3
ECM1 extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FADS1 fatty acid desaturase 1
FGFR1 fibroblast growth factor receptor 1
FOXO4 forkhead box O4
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPNMB glycoprotein (transmembrane) nmb
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
ISLR immunoglobulin superfamily containing leucine-rich repeat
KRT23 keratin 23, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LINC00341 long intergenic non-protein coding RNA 341
LPAR6 lysophosphatidic acid receptor 6
LY96 lymphocyte antigen 96
MAOA monoamine oxidase A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTSS1 metastasis suppressor 1
MVP major vault protein
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAM peptidylglycine alpha-amidating monooxygenase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PFKM phosphofructokinase, muscle
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLIN2 perilipin 2
PLTP phospholipid transfer protein
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PSAP prosaposin
PYGL phosphorylase, glycogen, liver
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
STMN2 stathmin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNGR3 synaptogyrin 3
SYT1 synaptotagmin I
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TSKU tsukushi, small leucine rich proteoglycan
TWF2 twinfilin actin binding protein 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CXCL13 chemokine (C-X-C motif) ligand 13
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DPH2 DPH2 homolog (S. cerevisiae)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
ICAM3 intercellular adhesion molecule 3
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MRPS2 mitochondrial ribosomal protein S2
MYCBP MYC binding protein
NFIB nuclear factor I/B
NPM3 nucleophosmin/nucleoplasmin 3
NUP98 nucleoporin 98kDa
PAEP progestagen-associated endometrial protein
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA3 replication protein A3, 14kDa
SCEL sciellin
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIPIN TIMELESS interacting protein
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1