BRD-K98824517_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K98824517_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ATF3 activating transcription factor 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
CCL19 chemokine (C-C motif) ligand 19
CD52 CD52 molecule
CFD complement factor D (adipsin)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL6A3 collagen, type VI, alpha 3
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTIP cytohesin 1 interacting protein
DES desmin
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GMPR guanosine monophosphate reductase
H1FX H1 histone family, member X
H3F3B H3 histone, family 3B (H3.3B)
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
IER2 immediate early response 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LTB lymphotoxin beta (TNF superfamily, member 3)
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MATN2 matrilin 2
MCTP1 multiple C2 domains, transmembrane 1
MMP7 matrix metallopeptidase 7
MUC5B mucin 5B, oligomeric mucus/gel-forming
NR4A1 nuclear receptor subfamily 4, group A, member 1
PCP4 Purkinje cell protein 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PRKCA protein kinase C, alpha
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TRIB1 tribbles pseudokinase 1
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VCAN versican
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA3 annexin A3
BMI1 BMI1 proto-oncogene, polycomb ring finger
CCNG1 cyclin G1
CD44 CD44 molecule (Indian blood group)
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
EFNB2 ephrin-B2
GJA1 gap junction protein, alpha 1, 43kDa
IFI44L interferon-induced protein 44-like
KIF1B kinesin family member 1B
KRT17 keratin 17, type I
LAMP1 lysosomal-associated membrane protein 1
LBH limb bud and heart development
LIMCH1 LIM and calponin homology domains 1
LPAR1 lysophosphatidic acid receptor 1
MFAP5 microfibrillar associated protein 5
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
PALLD palladin, cytoskeletal associated protein
PFN2 profilin 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
SESN1 sestrin 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIP6 thyroid hormone receptor interactor 6
YES1 YES proto-oncogene 1, Src family tyrosine kinase