BRD-K98824517_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K98824517_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRL2 adhesion G protein-coupled receptor L2
ANXA1 annexin A1
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
COL6A2 collagen, type VI, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DPYD dihydropyrimidine dehydrogenase
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM129A family with sequence similarity 129, member A
FAM49A family with sequence similarity 49, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPT microtubule-associated protein tau
MATN2 matrilin 2
MSX1 msh homeobox 1
NLGN4X neuroligin 4, X-linked
PRR15L proline rich 15-like
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SNAI2 snail family zinc finger 2
STC1 stanniocalcin 1
STEAP3 STEAP family member 3, metalloreductase
SUSD4 sushi domain containing 4
TACSTD2 tumor-associated calcium signal transducer 2
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM255A transmembrane protein 255A
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ALCAM activated leukocyte cell adhesion molecule
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
C6ORF62 chromosome 6 open reading frame 62
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CRIP1 cysteine-rich protein 1 (intestinal)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTTN cortactin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EIF4B eukaryotic translation initiation factor 4B
EMX2 empty spiracles homeobox 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FOLR1 folate receptor 1 (adult)
ICA1 islet cell autoantigen 1, 69kDa
MAP7 microtubule-associated protein 7
NNMT nicotinamide N-methyltransferase
PAWR PRKC, apoptosis, WT1, regulator
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCZ protein kinase C, zeta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS5 regulator of G-protein signaling 5
SCARB2 scavenger receptor class B, member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STX16 syntaxin 16
SYNGR3 synaptogyrin 3
TCF4 transcription factor 4
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
WSB2 WD repeat and SOCS box containing 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1