BRD-K98824517_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

265 genes differentially expressed following the BRD-K98824517_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AMOTL2 angiomotin like 2
ANG angiogenin, ribonuclease, RNase A family, 5
ARC activity-regulated cytoskeleton-associated protein
ARG2 arginase 2
ATF3 activating transcription factor 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCL2A1 BCL2-related protein A1
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2AIP CDKN2A interacting protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
COL6A2 collagen, type VI, alpha 2
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DEFA4 defensin, alpha 4, corticostatin
DHCR24 24-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
EFHD1 EF-hand domain family, member D1
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FAM134B family with sequence similarity 134, member B
FEM1C fem-1 homolog c (C. elegans)
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSN gelsolin
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IL11 interleukin 11
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRF6 interferon regulatory factor 6
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LST1 leukocyte specific transcript 1
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NCF2 neutrophil cytosolic factor 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
OLFML2A olfactomedin-like 2A
OSBPL10 oxysterol binding protein-like 10
OSER1 oxidative stress responsive serine-rich 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNASE4 ribonuclease, RNase A family, 4
RND1 Rho family GTPase 1
RND3 Rho family GTPase 3
RRAD Ras-related associated with diabetes
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
TGIF1 TGFB-induced factor homeobox 1
THBD thrombomodulin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UGCG UDP-glucose ceramide glucosyltransferase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACOT9 acyl-CoA thioesterase 9
ASPH aspartate beta-hydroxylase
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
CBX5 chromobox homolog 5
CCNF cyclin F
CNOT4 CCR4-NOT transcription complex, subunit 4
COCH cochlin
DACH1 dachshund family transcription factor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM129A family with sequence similarity 129, member A
FAM208A family with sequence similarity 208, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
GDE1 glycerophosphodiester phosphodiesterase 1
HLTF helicase-like transcription factor
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LINC00341 long intergenic non-protein coding RNA 341
MTDH metadherin
NFIB nuclear factor I/B
NUP62 nucleoporin 62kDa
PAM peptidylglycine alpha-amidating monooxygenase
PCP4 Purkinje cell protein 4
PDE10A phosphodiesterase 10A
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PODXL podocalyxin-like
PPARG peroxisome proliferator-activated receptor gamma
PRDX4 peroxiredoxin 4
PSCA prostate stem cell antigen
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
SENP6 SUMO1/sentrin specific peptidase 6
SEPHS1 selenophosphate synthetase 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SNX6 sorting nexin 6
SRPX sushi-repeat containing protein, X-linked
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM9SF2 transmembrane 9 superfamily member 2
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TUBGCP3 tubulin, gamma complex associated protein 3
TYRP1 tyrosinase-related protein 1
WSB2 WD repeat and SOCS box containing 2