BRD-K98731749_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K98731749_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE40 basic helix-loop-helix family, member e40
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP4 dual specificity phosphatase 4
EIF5 eukaryotic translation initiation factor 5
FADS1 fatty acid desaturase 1
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PTGES prostaglandin E synthase
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
STC2 stanniocalcin 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM45A transmembrane protein 45A
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
CADM1 cell adhesion molecule 1
CANT1 calcium activated nucleotidase 1
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CPE carboxypeptidase E
DUOX2 dual oxidase 2
EFNB2 ephrin-B2
FABP1 fatty acid binding protein 1, liver
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP7 insulin-like growth factor binding protein 7
JMJD6 jumonji domain containing 6
MUC2 mucin 2, oligomeric mucus/gel-forming
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOX3 TOX high mobility group box family member 3
TUBB2A tubulin, beta 2A class IIa