BRD-K98548675_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

210 genes differentially expressed following the BRD-K98548675_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMACR alpha-methylacyl-CoA racemase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BMP6 bone morphogenetic protein 6
CAV2 caveolin 2
CD58 CD58 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC4 chloride intracellular channel 4
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP5 dual specificity phosphatase 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GOLM1 golgi membrane protein 1
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NMRK1 nicotinamide riboside kinase 1
NNMT nicotinamide N-methyltransferase
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PERP PERP, TP53 apoptosis effector
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SDCBP syndecan binding protein (syntenin)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SH3BP4 SH3-domain binding protein 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
SRGN serglycin
STEAP1 six transmembrane epithelial antigen of the prostate 1
STXBP1 syntaxin binding protein 1
TESK1 testis-specific kinase 1
TMEM47 transmembrane protein 47
TPST2 tyrosylprotein sulfotransferase 2
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
WBP2 WW domain binding protein 2
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTG2 actin, gamma 2, smooth muscle, enteric
AGR2 anterior gradient 2
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID5B AT rich interactive domain 5B (MRF1-like)
B3GNT1
BTBD3 BTB (POZ) domain containing 3
C3 complement component 3
C7 complement component 7
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL15A1 collagen, type XV, alpha 1
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CSTA cystatin A (stefin A)
CTSH cathepsin H
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTX4 deltex 4, E3 ubiquitin ligase
EDNRA endothelin receptor type A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA2 GATA binding protein 2
GPC3 glypican 3
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPRC5B G protein-coupled receptor, class C, group 5, member B
GREB1 growth regulation by estrogen in breast cancer 1
HEATR1 HEAT repeat containing 1
HES1 hes family bHLH transcription factor 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KIAA0922 KIAA0922
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAOB monoamine oxidase B
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MB myoglobin
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MGLL monoglyceride lipase
MGP matrix Gla protein
MINA MYC induced nuclear antigen
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
OBSL1 obscurin-like 1
PDE9A phosphodiesterase 9A
PEG10 paternally expressed 10
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAT plasminogen activator, tissue
PLLP plasmolipin
POSTN periostin, osteoblast specific factor
PRR15L proline rich 15-like
PTBP2 polypyrimidine tract binding protein 2
PVALB parvalbumin
RAB25 RAB25, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS10 regulator of G-protein signaling 10
SALL2 spalt-like transcription factor 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SEPW1 selenoprotein W, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SOBP sine oculis binding protein homolog (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR3 transforming growth factor, beta receptor III
TJP2 tight junction protein 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNNC1 troponin C type 1 (slow)
TNNI2 troponin I type 2 (skeletal, fast)
TNS3 tensin 3
TRIL TLR4 interactor with leucine-rich repeats
TRPS1 trichorhinophalangeal syndrome I
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican
WFDC2 WAP four-disulfide core domain 2
ZNF185 zinc finger protein 185 (LIM domain)