BRD-K98548675_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K98548675_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BCAP31 B-cell receptor-associated protein 31
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
BLVRB biliverdin reductase B
C1ORF106 chromosome 1 open reading frame 106
C1ORF116 chromosome 1 open reading frame 116
CAPN2 calpain 2, (m/II) large subunit
CBR3 carbonyl reductase 3
CCR2 chemokine (C-C motif) receptor 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CES1 carboxylesterase 1
CLPTM1 cleft lip and palate associated transmembrane protein 1
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DUSP5 dual specificity phosphatase 5
ELF4 E74-like factor 4 (ets domain transcription factor)
ELOVL1 ELOVL fatty acid elongase 1
EMC3 ER membrane protein complex subunit 3
EPAS1 endothelial PAS domain protein 1
FGFR2 fibroblast growth factor receptor 2
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAREM GRB2 associated, regulator of MAPK1
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GPX2 glutathione peroxidase 2
GRB7 growth factor receptor-bound protein 7
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HPSE heparanase
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGKV1-5 immunoglobulin kappa variable 1-5
IL13RA1 interleukin 13 receptor, alpha 1
INHBB inhibin, beta B
IPO13 importin 13
IQGAP1 IQ motif containing GTPase activating protein 1
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LAMP2 lysosomal-associated membrane protein 2
LRP10 low density lipoprotein receptor-related protein 10
LYPD3 LY6/PLAUR domain containing 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NPAS2 neuronal PAS domain protein 2
OBSL1 obscurin-like 1
PEA15 phosphoprotein enriched in astrocytes 15
PERP PERP, TP53 apoptosis effector
PLXNB2 plexin B2
RAP1GAP RAP1 GTPase activating protein
RIN2 Ras and Rab interactor 2
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SDC4 syndecan 4
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SNX7 sorting nexin 7
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TDO2 tryptophan 2,3-dioxygenase
TES testin LIM domain protein
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM4 tropomyosin 4
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TUBA4A tubulin, alpha 4a
TXNRD1 thioredoxin reductase 1
VCAM1 vascular cell adhesion molecule 1
VGLL1 vestigial-like family member 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
ASRGL1 asparaginase like 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
CDC25A cell division cycle 25A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFI complement factor I
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DHFR dihydrofolate reductase
DLC1 DLC1 Rho GTPase activating protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
ELOVL2 ELOVL fatty acid elongase 2
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FABP1 fatty acid binding protein 1, liver
FCGBP Fc fragment of IgG binding protein
HADH hydroxyacyl-CoA dehydrogenase
HMGB2 high mobility group box 2
HOXB6 homeobox B6
HOXC6 homeobox C6
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
IL6ST interleukin 6 signal transducer
ISG15 ISG15 ubiquitin-like modifier
ISOC1 isochorismatase domain containing 1
KIAA0101 KIAA0101
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
MGP matrix Gla protein
MT1E metallothionein 1E
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCGF2 polycomb group ring finger 2
PDZK1 PDZ domain containing 1
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RELN reelin
SEC23A Sec23 homolog A (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPDEF SAM pointed domain containing ETS transcription factor
SRPX sushi-repeat containing protein, X-linked
SYBU syntabulin (syntaxin-interacting)
TFF3 trefoil factor 3 (intestinal)
TMEM14B transmembrane protein 14B
TSPAN6 tetraspanin 6