BRD-K98519396_NP-010155_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K98519396_NP-010155_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCY7 adenylate cyclase 7
ADGRE5 adhesion G protein-coupled receptor E5
AIM2 absent in melanoma 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPT1 angiopoietin 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CHI3L2 chitinase 3-like 2
CLU clusterin
COL6A3 collagen, type VI, alpha 3
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
DSP desmoplakin
EDNRB endothelin receptor type B
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM46A family with sequence similarity 46, member A
FYB FYN binding protein
GPATCH8 G patch domain containing 8
GPM6A glycoprotein M6A
GSTA4 glutathione S-transferase alpha 4
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H2AFZ H2A histone family, member Z
HNMT histamine N-methyltransferase
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RB interleukin 2 receptor, beta
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITK IL2-inducible T-cell kinase
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KYNU kynureninase
LTF lactotransferrin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSX1 msh homeobox 1
NAMPT nicotinamide phosphoribosyltransferase
NES nestin
NQO2 NAD(P)H dehydrogenase, quinone 2
NTS neurotensin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDLIM1 PDZ and LIM domain 1
PRF1 perforin 1 (pore forming protein)
PTX3 pentraxin 3, long
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE4 ribonuclease, RNase A family, 4
S100A11 S100 calcium binding protein A11
S100A9 S100 calcium binding protein A9
SELL selectin L
SFN stratifin
SLA Src-like-adaptor
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TMEM147 transmembrane protein 147
TNC tenascin C
TRBC1 T cell receptor beta constant 1
TUBB2A tubulin, beta 2A class IIa
UBE2S ubiquitin-conjugating enzyme E2S
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
APP amyloid beta (A4) precursor protein
ASPN asporin
BHLHE41 basic helix-loop-helix family, member e41
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CD9 CD9 molecule
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CXCL14 chemokine (C-X-C motif) ligand 14
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF5 eukaryotic translation initiation factor 5
EIF5B eukaryotic translation initiation factor 5B
FBXO21 F-box protein 21
FRZB frizzled-related protein
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GAGE3 G antigen 3
HBB hemoglobin, beta
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA2 heat shock 70kDa protein 2
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ITM2B integral membrane protein 2B
JCHAIN joining chain of multimeric IgA and IgM
MMP3 matrix metallopeptidase 3
PDGFRL platelet-derived growth factor receptor-like
PKP2 plakophilin 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSPH phosphoserine phosphatase
PXDN peroxidasin
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCG5 secretogranin V
SFRP4 secreted frizzled-related protein 4
SLC38A1 solute carrier family 38, member 1
STK10 serine/threonine kinase 10
THBS1 thrombospondin 1
TMEM30B transmembrane protein 30B
TXNDC9 thioredoxin domain containing 9
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395