BRD-K98490050_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K98490050_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ASPN asporin
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BIRC3 baculoviral IAP repeat containing 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
EGFL6 EGF-like-domain, multiple 6
GCH1 GTP cyclohydrolase 1
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
GSPT2 G1 to S phase transition 2
HCCS holocytochrome c synthase
HLX H2.0-like homeobox
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT14 keratin 14, type I
KRT5 keratin 5, type II
MAP7 microtubule-associated protein 7
MMP12 matrix metallopeptidase 12
NCF2 neutrophil cytosolic factor 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PBX3 pre-B-cell leukemia homeobox 3
PECAM1 platelet/endothelial cell adhesion molecule 1
PELI1 pellino E3 ubiquitin protein ligase 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRAME preferentially expressed antigen in melanoma
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS5 regulator of G-protein signaling 5
SCG2 secretogranin II
SFN stratifin
SHOX2 short stature homeobox 2
SULF1 sulfatase 1
THBS1 thrombospondin 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AHNAK AHNAK nucleoprotein
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
COG2 component of oligomeric golgi complex 2
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FOXG1 forkhead box G1
FXYD5 FXYD domain containing ion transport regulator 5
GATA2 GATA binding protein 2
GPSM2 G-protein signaling modulator 2
GYPC glycophorin C (Gerbich blood group)
HBD hemoglobin, delta
HMMR hyaluronan-mediated motility receptor (RHAMM)
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LAMP1 lysosomal-associated membrane protein 1
LOC100505650 uncharacterized LOC100505650
MALL mal, T-cell differentiation protein-like
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MLPH melanophilin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDNF neuron-derived neurotrophic factor
NEK2 NIMA-related kinase 2
NRGN neurogranin (protein kinase C substrate, RC3)
NRIP1 nuclear receptor interacting protein 1
PDZRN3 PDZ domain containing ring finger 3
PLA2G16 phospholipase A2, group XVI
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
RAB25 RAB25, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBP4 retinol binding protein 4, plasma
RHOBTB1 Rho-related BTB domain containing 1
RHOBTB3 Rho-related BTB domain containing 3
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TPX2 TPX2, microtubule-associated
TSPAN1 tetraspanin 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VLDLR very low density lipoprotein receptor
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYND8 zinc finger, MYND-type containing 8