BRD-K98143437_SB 239063_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K98143437_SB 239063_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA1 annexin A1
APOD apolipoprotein D
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BHLHE41 basic helix-loop-helix family, member e41
CD4 CD4 molecule
COL4A2 collagen, type IV, alpha 2
CST3 cystatin C
DEFB1 defensin, beta 1
DPP4 dipeptidyl-peptidase 4
E2F2 E2F transcription factor 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8 epidermal growth factor receptor pathway substrate 8
FOXC1 forkhead box C1
FXYD2 FXYD domain containing ion transport regulator 2
GLDC glycine dehydrogenase (decarboxylating)
GPX3 glutathione peroxidase 3
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGLJ3 immunoglobulin lambda joining 3
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT15 keratin 15, type I
LDHB lactate dehydrogenase B
MYH11 myosin, heavy chain 11, smooth muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NR2F2 nuclear receptor subfamily 2, group F, member 2
PYGL phosphorylase, glycogen, liver
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC16A4 solute carrier family 16, member 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP4 TIMP metallopeptidase inhibitor 4
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ASS1 argininosuccinate synthase 1
CA2 carbonic anhydrase II
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CERS6 ceramide synthase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
CREB1 cAMP responsive element binding protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5R2 cytochrome b5 reductase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFITM3 interferon induced transmembrane protein 3
IL13RA2 interleukin 13 receptor, alpha 2
MAB21L2 mab-21-like 2 (C. elegans)
MAN1A1 mannosidase, alpha, class 1A, member 1
MEG3 maternally expressed 3 (non-protein coding)
MFAP2 microfibrillar-associated protein 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERHL2 serine hydrolase-like 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPARCL1 SPARC-like 1 (hevin)
SPRED2 sprouty-related, EVH1 domain containing 2
SST somatostatin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPBG trophoblast glycoprotein
TWIST1 twist family bHLH transcription factor 1
ZFP36L1 ZFP36 ring finger protein-like 1