BRD-K97534490_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-K97534490_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AHCYL1 adenosylhomocysteinase-like 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA6 annexin A6
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BEX1 brain expressed, X-linked 1
C10ORF10 chromosome 10 open reading frame 10
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHMP2A charged multivesicular body protein 2A
COL9A3 collagen, type IX, alpha 3
CRABP2 cellular retinoic acid binding protein 2
DDIT4 DNA-damage-inducible transcript 4
DGAT1 diacylglycerol O-acyltransferase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DSG1 desmoglein 1
DUSP5 dual specificity phosphatase 5
ECHDC3 enoyl CoA hydratase domain containing 3
EFNA1 ephrin-A1
ENO2 enolase 2 (gamma, neuronal)
EPCAM epithelial cell adhesion molecule
FGG fibrinogen gamma chain
FLOT1 flotillin 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GRN granulin
HEPH hephaestin
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
IER3 immediate early response 3
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IGSF3 immunoglobulin superfamily, member 3
IVNS1ABP influenza virus NS1A binding protein
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KIF1B kinesin family member 1B
KIF5C kinesin family member 5C
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
LDLR low density lipoprotein receptor
LTBP3 latent transforming growth factor beta binding protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MSN moesin
MT1X metallothionein 1X
MTMR11 myotubularin related protein 11
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NES nestin
NRN1 neuritin 1
OXTR oxytocin receptor
PAPOLA poly(A) polymerase alpha
PI3 peptidase inhibitor 3, skin-derived
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
PODXL podocalyxin-like
PPAP2B phosphatidic acid phosphatase type 2B
RAB40B RAB40B, member RAS oncogene family
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFTPB surfactant protein B
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STXBP1 syntaxin binding protein 1
SYNGR3 synaptogyrin 3
TACSTD2 tumor-associated calcium signal transducer 2
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN31 tetraspanin 31
VAT1 vesicle amine transport 1
VIM vimentin
YBX3 Y box binding protein 3
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD2 abhydrolase domain containing 2
ADAM28 ADAM metallopeptidase domain 28
ADGRG2 adhesion G protein-coupled receptor G2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKRD36B ankyrin repeat domain 36B
ATF5 activating transcription factor 5
BANK1 B-cell scaffold protein with ankyrin repeats 1
C9ORF3 chromosome 9 open reading frame 3
CADPS2 Ca++-dependent secretion activator 2
CCL19 chemokine (C-C motif) ligand 19
CCNE2 cyclin E2
CD40 CD40 molecule, TNF receptor superfamily member 5
CKS2 CDC28 protein kinase regulatory subunit 2
COMMD8 COMM domain containing 8
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYTIP cytohesin 1 interacting protein
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPNMB glycoprotein (transmembrane) nmb
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMK granzyme K (granzyme 3; tryptase II)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KEAP1 kelch-like ECH-associated protein 1
KYNU kynureninase
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MECOM MDS1 and EVI1 complex locus
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MMP12 matrix metallopeptidase 12
MRPS12 mitochondrial ribosomal protein S12
NANS N-acetylneuraminic acid synthase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
OSBPL10 oxysterol binding protein-like 10
PCDH7 protocadherin 7
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMM2 phosphomannomutase 2
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRPF4 pre-mRNA processing factor 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
RBM3 RNA binding motif (RNP1, RRM) protein 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A2 S100 calcium binding protein A2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SFPQ splicing factor proline/glutamine-rich
SFRP4 secreted frizzled-related protein 4
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMC2 structural maintenance of chromosomes 2
TBX2 T-box 2
TNS3 tensin 3
TWF1 twinfilin actin binding protein 1
TXNDC9 thioredoxin domain containing 9
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UPK1B uroplakin 1B
VDAC1 voltage-dependent anion channel 1