BRD-K97534490_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K97534490_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM28 ADAM metallopeptidase domain 28
AMIGO2 adhesion molecule with Ig-like domain 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAV1 caveolin 1, caveolae protein, 22kDa
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLC Charcot-Leyden crystal galectin
COL18A1 collagen, type XVIII, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CPA3 carboxypeptidase A3 (mast cell)
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLNA filamin A, alpha
FOXF2 forkhead box F2
FST follistatin
G0S2 G0/G1 switch 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOMER3 homer scaffolding protein 3
HOXB2 homeobox B2
HOXB6 homeobox B6
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LCN2 lipocalin 2
MEIS2 Meis homeobox 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MVP major vault protein
NDRG1 N-myc downstream regulated 1
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PRTN3 proteinase 3
RAP1GAP RAP1 GTPase activating protein
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TAGLN transgelin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCY1 adenylate cyclase 1 (brain)
ADI1 acireductone dioxygenase 1
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
APOD apolipoprotein D
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BACE2 beta-site APP-cleaving enzyme 2
C3 complement component 3
CA12 carbonic anhydrase XII
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CLU clusterin
CNPY2 canopy FGF signaling regulator 2
CTNND1 catenin (cadherin-associated protein), delta 1
CTSH cathepsin H
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DERA deoxyribose-phosphate aldolase (putative)
DLD dihydrolipoamide dehydrogenase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EAPP E2F-associated phosphoprotein
EGR3 early growth response 3
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FEN1 flap structure-specific endonuclease 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GSPT2 G1 to S phase transition 2
HACD2 3-hydroxyacyl-CoA dehydratase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
IGF1 insulin-like growth factor 1 (somatomedin C)
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KRT14 keratin 14, type I
MAGED1 melanoma antigen family D1
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MREG melanoregulin
NBN nibrin
NEBL nebulette
NEFL neurofilament, light polypeptide
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PBK PDZ binding kinase
PCDH9 protocadherin 9
PCNA proliferating cell nuclear antigen
PDGFRL platelet-derived growth factor receptor-like
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRDX1 peroxiredoxin 1
PROM1 prominin 1
PUF60 poly-U binding splicing factor 60KDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RSL1D1 ribosomal L1 domain containing 1
SELT selenoprotein T
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TFRC transferrin receptor
TMEM243 transmembrane protein 243, mitochondrial
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TOR1AIP1 torsin A interacting protein 1
TRAM1 translocation associated membrane protein 1
TSPYL5 TSPY-like 5
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UBE3C ubiquitin protein ligase E3C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
XBP1 X-box binding protein 1
XPO7 exportin 7
ZNF185 zinc finger protein 185 (LIM domain)