BRD-K97330509_Src Kinase Inhibitor II_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

187 genes differentially expressed following the BRD-K97330509_Src Kinase Inhibitor II_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AVL9 AVL9 homolog (S. cerevisiase)
CARS cysteinyl-tRNA synthetase
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
HMGA2 high mobility group AT-hook 2
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
JUN jun proto-oncogene
MINA MYC induced nuclear antigen
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NARS asparaginyl-tRNA synthetase
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SARS seryl-tRNA synthetase
SATB2 SATB homeobox 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD1 SMAD family member 1
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TCEA1 transcription elongation factor A (SII), 1
TGIF1 TGFB-induced factor homeobox 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADGRG1 adhesion G protein-coupled receptor G1
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
ANXA6 annexin A6
AQP3 aquaporin 3 (Gill blood group)
ASCL1 achaete-scute family bHLH transcription factor 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BCHE butyrylcholinesterase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF3 chromosome 9 open reading frame 3
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFI complement factor I
CNN1 calponin 1, basic, smooth muscle
COL5A1 collagen, type V, alpha 1
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
DES desmin
DHCR7 7-dehydrocholesterol reductase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FADS1 fatty acid desaturase 1
FAM162A family with sequence similarity 162, member A
FAM69A family with sequence similarity 69, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GJA1 gap junction protein, alpha 1, 43kDa
GPI glucose-6-phosphate isomerase
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA2 heat shock 70kDa protein 2
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSIG1 insulin induced gene 1
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MEIS2 Meis homeobox 2
MGAM maltase-glucoamylase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPTX2 neuronal pentraxin II
NSG1 neuron specific gene family member 1
NTS neurotensin
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PDE10A phosphodiesterase 10A
PDIA6 protein disulfide isomerase family A, member 6
PDLIM1 PDZ and LIM domain 1
PDLIM3 PDZ and LIM domain 3
PENK proenkephalin
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PKM pyruvate kinase, muscle
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS23 protease, serine, 23
PRUNE2 prune homolog 2 (Drosophila)
PTHLH parathyroid hormone-like hormone
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL37A ribosomal protein L37a
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
TMEM14A transmembrane protein 14A
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM4 tropomyosin 4
WFS1 Wolfram syndrome 1 (wolframin)
XIST X inactive specific transcript (non-protein coding)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble