BRD-K97309399_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K97309399_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ANXA3 annexin A3
ANXA4 annexin A4
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLC Charcot-Leyden crystal galectin
CST1 cystatin SN
CYB5R1 cytochrome b5 reductase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
EPHA2 EPH receptor A2
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS1 fatty acid desaturase 1
FDPS farnesyl diphosphate synthase
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP2 guanylate binding protein 2, interferon-inducible
GM2A GM2 ganglioside activator
GPR87 G protein-coupled receptor 87
GSN gelsolin
H1F0 H1 histone family, member 0
HLA-B major histocompatibility complex, class I, B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
INSIG1 insulin induced gene 1
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT81 keratin 81, type II
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LYST lysosomal trafficking regulator
MOSPD1 motile sperm domain containing 1
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC2 Niemann-Pick disease, type C2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PRSS8 protease, serine, 8
PSAP prosaposin
PYCARD PYD and CARD domain containing
RAP1GAP RAP1 GTPase activating protein
RPS27L ribosomal protein S27-like
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SFN stratifin
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SOCS2 suppressor of cytokine signaling 2
SQLE squalene epoxidase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
TP53I3 tumor protein p53 inducible protein 3
TRIM2 tripartite motif containing 2
TRIM29 tripartite motif containing 29
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDK6 cyclin-dependent kinase 6
CENPA centromere protein A
CHRDL1 chordin-like 1
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HOXC10 homeobox C10
HSPD1 heat shock 60kDa protein 1 (chaperonin)
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MIS18A MIS18 kinetochore protein A
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
RHOBTB3 Rho-related BTB domain containing 3
RRM1 ribonucleotide reductase M1
SERBP1 SERPINE1 mRNA binding protein 1
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
TNC tenascin C
TSPAN13 tetraspanin 13
UBE2S ubiquitin-conjugating enzyme E2S