BRD-K97056771_HY-11007_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K97056771_HY-11007_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
BPHL biphenyl hydrolase-like (serine hydrolase)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN3 claudin 3
CYFIP2 cytoplasmic FMR1 interacting protein 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EMX2 empty spiracles homeobox 2
HOOK2 hook microtubule-tethering protein 2
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
LRMP lymphoid-restricted membrane protein
LY6E lymphocyte antigen 6 complex, locus E
MTUS1 microtubule associated tumor suppressor 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFD platelet derived growth factor D
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS2 regulator of G-protein signaling 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SST somatostatin
SULF1 sulfatase 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TRAPPC6A trafficking protein particle complex 6A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ANXA1 annexin A1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHPT1 choline phosphotransferase 1
CLEC11A C-type lectin domain family 11, member A
COBL cordon-bleu WH2 repeat protein
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
F13A1 coagulation factor XIII, A1 polypeptide
FABP7 fatty acid binding protein 7, brain
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GOLGA8B golgin A8 family, member B
GPRC5A G protein-coupled receptor, class C, group 5, member A
ISG20 interferon stimulated exonuclease gene 20kDa
ISOC1 isochorismatase domain containing 1
ITM2A integral membrane protein 2A
LCN2 lipocalin 2
LMO4 LIM domain only 4
MAN1A1 mannosidase, alpha, class 1A, member 1
NFIB nuclear factor I/B
PEX11A peroxisomal biogenesis factor 11 alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTCH1 patched 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLPI secretory leukocyte peptidase inhibitor
TACSTD2 tumor-associated calcium signal transducer 2
TM4SF1 transmembrane 4 L six family member 1
TM9SF3 transmembrane 9 superfamily member 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
WNT5A wingless-type MMTV integration site family, member 5A