BRD-K96799727_Pifithrin- ?_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K96799727_Pifithrin- ?_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
COL5A2 collagen, type V, alpha 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
FTH1 ferritin, heavy polypeptide 1
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
JCHAIN joining chain of multimeric IgA and IgM
MAOA monoamine oxidase A
MBOAT7 membrane bound O-acyltransferase domain containing 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
PCDH9 protocadherin 9
PEA15 phosphoprotein enriched in astrocytes 15
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TRAPPC3 trafficking protein particle complex 3
TXNRD1 thioredoxin reductase 1
XPOT exportin, tRNA

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACTN1 actinin, alpha 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCY adenosylhomocysteinase
ANXA3 annexin A3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL11A1 collagen, type XI, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYFIP2 cytoplasmic FMR1 interacting protein 2
DLK1 delta-like 1 homolog (Drosophila)
EGR3 early growth response 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GCH1 GTP cyclohydrolase 1
GLDC glycine dehydrogenase (decarboxylating)
GRN granulin
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
LTF lactotransferrin
MARCKSL1 MARCKS-like 1
MCOLN1 mucolipin 1
NFIB nuclear factor I/B
OAT ornithine aminotransferase
PLAC8 placenta-specific 8
PROM1 prominin 1
PTK2 protein tyrosine kinase 2
PUF60 poly-U binding splicing factor 60KDa
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPTBN1 spectrin, beta, non-erythrocytic 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TPM1 tropomyosin 1 (alpha)
VGLL4 vestigial-like family member 4