BRD-K96799727_-666_MDST8_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K96799727_-666_MDST8_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARMCX2 armadillo repeat containing, X-linked 2
BAG3 BCL2-associated athanogene 3
CA12 carbonic anhydrase XII
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD163 CD163 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLIC4 chloride intracellular channel 4
CSRP1 cysteine and glycine-rich protein 1
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYNLT3 dynein, light chain, Tctex-type 3
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FKBP11 FK506 binding protein 11, 19 kDa
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GPNMB glycoprotein (transmembrane) nmb
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HOXC10 homeobox C10
HSPA1A heat shock 70kDa protein 1A
IGFBP5 insulin-like growth factor binding protein 5
IGKV4-1 immunoglobulin kappa variable 4-1
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
KIF5C kinesin family member 5C
LAPTM4B lysosomal protein transmembrane 4 beta
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEST mesoderm specific transcript
MFAP5 microfibrillar associated protein 5
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLIN2 perilipin 2
PTGIS prostaglandin I2 (prostacyclin) synthase
S100A9 S100 calcium binding protein A9
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD1 SMAD family member 1
SPG20 spastic paraplegia 20 (Troyer syndrome)
SSBP2 single-stranded DNA binding protein 2
TPST2 tyrosylprotein sulfotransferase 2
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VSIG4 V-set and immunoglobulin domain containing 4
WDR7 WD repeat domain 7
ZNF331 zinc finger protein 331
ZNF395 zinc finger protein 395
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ALDOB aldolase B, fructose-bisphosphate
ANG angiogenin, ribonuclease, RNase A family, 5
BIRC3 baculoviral IAP repeat containing 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFHR4 complement factor H-related 4
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL10 chemokine (C-X-C motif) ligand 10
CYB5A cytochrome b5 type A (microsomal)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
EDNRB endothelin receptor type B
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FAIM Fas apoptotic inhibitory molecule
FPGS folylpolyglutamate synthase
GBP1 guanylate binding protein 1, interferon-inducible
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPRC5A G protein-coupled receptor, class C, group 5, member A
HLF hepatic leukemia factor
HMG20B high mobility group 20B
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT8 keratin 8, type II
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MME membrane metallo-endopeptidase
MUC2 mucin 2, oligomeric mucus/gel-forming
NEBL nebulette
NR2F1 nuclear receptor subfamily 2, group F, member 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP prolactin-induced protein
PLP1 proteolipid protein 1
PXDN peroxidasin
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SORD sorbitol dehydrogenase
TMEM176A transmembrane protein 176A
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VSNL1 visinin-like 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L1 ZFP36 ring finger protein-like 1