BRD-K96799727_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-K96799727_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHMT2 betaine--homocysteine S-methyltransferase 2
BRD2 bromodomain containing 2
CBR3 carbonyl reductase 3
CCND3 cyclin D3
CD163 CD163 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L2 chitinase 3-like 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
COL11A1 collagen, type XI, alpha 1
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EMP3 epithelial membrane protein 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCMR Fc fragment of IgM receptor
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GPC1 glypican 1
GPX2 glutathione peroxidase 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGA1 high mobility group AT-hook 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
IL6R interleukin 6 receptor
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JMJD6 jumonji domain containing 6
LBH limb bud and heart development
LBR lamin B receptor
LY6D lymphocyte antigen 6 complex, locus D
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1B microtubule-associated protein 1B
MAP2K3 mitogen-activated protein kinase kinase 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP3 matrix metallopeptidase 3
NAMPT nicotinamide phosphoribosyltransferase
NDFIP1 Nedd4 family interacting protein 1
NKX3-1 NK3 homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
ODC1 ornithine decarboxylase 1
PELI1 pellino E3 ubiquitin protein ligase 1
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SATB2 SATB homeobox 2
SERINC5 serine incorporator 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC38A6 solute carrier family 38, member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOD2 superoxide dismutase 2, mitochondrial
SPRR2B small proline-rich protein 2B
SQSTM1 sequestosome 1
SRRM2 serine/arginine repetitive matrix 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
WWC3 WWC family member 3

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACACB acetyl-CoA carboxylase beta
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGR2 anterior gradient 2
ANXA3 annexin A3
ANXA4 annexin A4
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B3GNT1
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNF cyclin F
CD24 CD24 molecule
CD81 CD81 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CSRP1 cysteine and glycine-rich protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DLD dihydrolipoamide dehydrogenase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EDNRA endothelin receptor type A
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAIM Fas apoptotic inhibitory molecule
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBLN1 fibulin 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA2 GATA binding protein 2
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KAT6B K(lysine) acetyltransferase 6B
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC17 leucine rich repeat containing 17
LXN latexin
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MGLL monoglyceride lipase
MGP matrix Gla protein
MT1E metallothionein 1E
MYH11 myosin, heavy chain 11, smooth muscle
MYOF myoferlin
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
PBX1 pre-B-cell leukemia homeobox 1
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLN phospholamban
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
PRR15L proline rich 15-like
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RIN2 Ras and Rab interactor 2
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TACSTD2 tumor-associated calcium signal transducer 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPBG trophoblast glycoprotein
TRIL TLR4 interactor with leucine-rich repeats
TRIP6 thyroid hormone receptor interactor 6
TSC22D3 TSC22 domain family, member 3
VCAN versican
WFDC2 WAP four-disulfide core domain 2