BRD-K96799727_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K96799727_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BAG3 BCL2-associated athanogene 3
BLMH bleomycin hydrolase
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CD58 CD58 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CRISP3 cysteine-rich secretory protein 3
CTSB cathepsin B
CTSL cathepsin L
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP1 dual specificity phosphatase 1
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
JUN jun proto-oncogene
KEAP1 kelch-like ECH-associated protein 1
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LYPD3 LY6/PLAUR domain containing 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTCL1 microtubule crosslinking factor 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PFN2 profilin 2
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PLTP phospholipid transfer protein
PPIF peptidylprolyl isomerase F
RAP1GAP RAP1 GTPase activating protein
S100A10 S100 calcium binding protein A10
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TKT transketolase
TM4SF1 transmembrane 4 L six family member 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ANXA3 annexin A3
B3GNT1
BCHE butyrylcholinesterase
CD24 CD24 molecule
DHCR24 24-dehydrocholesterol reductase
EFHD1 EF-hand domain family, member D1
ERBB2 erb-b2 receptor tyrosine kinase 2
GATA2 GATA binding protein 2
LRRN3 leucine rich repeat neuronal 3
LUM lumican
MXRA5 matrix-remodelling associated 5
MYRF myelin regulatory factor
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SFRP1 secreted frizzled-related protein 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
VCAN versican
VNN1 vanin 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta