BRD-K96799727_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K96799727_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
BRD4 bromodomain containing 4
CA2 carbonic anhydrase II
CCR1 chemokine (C-C motif) receptor 1
CD163 CD163 molecule
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELF2 CUGBP, Elav-like family member 2
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
CTSK cathepsin K
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DICER1 dicer 1, ribonuclease type III
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGR1 early growth response 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPNMB glycoprotein (transmembrane) nmb
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
ISLR immunoglobulin superfamily containing leucine-rich repeat
KEAP1 kelch-like ECH-associated protein 1
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP11 matrix metallopeptidase 11
MMP9 matrix metallopeptidase 9
NCOA3 nuclear receptor coactivator 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLEKHO2 pleckstrin homology domain containing, family O member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD1 SMAD family member 1
SQSTM1 sequestosome 1
SRGN serglycin
SRRM2 serine/arginine repetitive matrix 2
TDO2 tryptophan 2,3-dioxygenase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHRDL1 chordin-like 1
CLDN18 claudin 18
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DPH2 DPH2 homolog (S. cerevisiae)
DUOX2 dual oxidase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP7 fatty acid binding protein 7, brain
FAIM Fas apoptotic inhibitory molecule
FAM107A family with sequence similarity 107, member A
GPX3 glutathione peroxidase 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
KRT18 keratin 18, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MCAM melanoma cell adhesion molecule
NAV2 neuron navigator 2
NRN1 neuritin 1
PLA2G16 phospholipase A2, group XVI
PLN phospholamban
PNMA2 paraneoplastic Ma antigen 2
PPARG peroxisome proliferator-activated receptor gamma
RBPMS RNA binding protein with multiple splicing
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TXNIP thioredoxin interacting protein
TYRP1 tyrosinase-related protein 1
WWTR1 WW domain containing transcription regulator 1