BRD-K96076993_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

262 genes differentially expressed following the BRD-K96076993_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BANP BTG3 associated nuclear protein
BCL6 B-cell CLL/lymphoma 6
BMP4 bone morphogenetic protein 4
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CCNL1 cyclin L1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CNOT4 CCR4-NOT transcription complex, subunit 4
COL1A1 collagen, type I, alpha 1
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA0753 KIAA0753
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRCC1 lysine-rich coiled-coil 1
KTN1 kinectin 1 (kinesin receptor)
LARP6 La ribonucleoprotein domain family, member 6
LUM lumican
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MOK MOK protein kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRBF2 nuclear receptor binding factor 2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
NXF1 nuclear RNA export factor 1
OBSL1 obscurin-like 1
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
QPCT glutaminyl-peptide cyclotransferase
RBM34 RNA binding motif protein 34
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RND3 Rho family GTPase 3
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SCG5 secretogranin V
SCYL3 SCY1-like 3 (S. cerevisiae)
SENP6 SUMO1/sentrin specific peptidase 6
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFRP1 secreted frizzled-related protein 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SOX9 SRY (sex determining region Y)-box 9
STAR steroidogenic acute regulatory protein
TBX2 T-box 2
TBX3 T-box 3
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TSC22D3 TSC22 domain family, member 3
TSPYL2 TSPY-like 2
TUFT1 tuftelin 1
UBE3C ubiquitin protein ligase E3C
VEGFA vascular endothelial growth factor A
ZBTB38 zinc finger and BTB domain containing 38
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZNF24 zinc finger protein 24
ZNF274 zinc finger protein 274
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AES amino-terminal enhancer of split
AHCYL1 adenosylhomocysteinase-like 1
AHNAK AHNAK nucleoprotein
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF5 activating transcription factor 5
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
CAST calpastatin
CCDC109B coiled-coil domain containing 109B
CCND1 cyclin D1
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES2 carboxylesterase 2
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DSTN destrin (actin depolymerizing factor)
EFHD1 EF-hand domain family, member D1
EI24 etoposide induced 2.4
ELOVL6 ELOVL fatty acid elongase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESR1 estrogen receptor 1
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM3C family with sequence similarity 3, member C
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
GLDC glycine dehydrogenase (decarboxylating)
GLUD1 glutamate dehydrogenase 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLM1 golgi membrane protein 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HMGB1 high mobility group box 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
INSIG1 insulin induced gene 1
IPO5 importin 5
IQGAP1 IQ motif containing GTPase activating protein 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS1 lectin, galactoside-binding, soluble, 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAN1A2 mannosidase, alpha, class 1A, member 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MGST3 microsomal glutathione S-transferase 3
MLEC malectin
MPPED2 metallophosphoesterase domain containing 2
MREG melanoregulin
MUC1 mucin 1, cell surface associated
MXRA7 matrix-remodelling associated 7
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAV2 neuron navigator 2
NDRG3 NDRG family member 3
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
PARP1 poly (ADP-ribose) polymerase 1
PEG10 paternally expressed 10
PI3 peptidase inhibitor 3, skin-derived
PRDX1 peroxiredoxin 1
PRKCD protein kinase C, delta
PSRC1 proline/serine-rich coiled-coil 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RIN2 Ras and Rab interactor 2
RPA1 replication protein A1, 70kDa
RPS26 ribosomal protein S26
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARB2 scavenger receptor class B, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT11 septin 11
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SOX4 SRY (sex determining region Y)-box 4
SRSF1 serine/arginine-rich splicing factor 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TACSTD2 tumor-associated calcium signal transducer 2
TARDBP TAR DNA binding protein
TM4SF1 transmembrane 4 L six family member 1
TMX4 thioredoxin-related transmembrane protein 4
TNS3 tensin 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN3 tetraspanin 3
TSPO translocator protein (18kDa)
UBL3 ubiquitin-like 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon