BRD-K96076993_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

297 genes differentially expressed following the BRD-K96076993_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ADORA2B adenosine A2b receptor
ANKRD11 ankyrin repeat domain 11
ANXA1 annexin A1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BTG3 BTG family, member 3
CAPN2 calpain 2, (m/II) large subunit
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
ERP44 endoplasmic reticulum protein 44
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FOXF2 forkhead box F2
FSCN1 fascin actin-bundling protein 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
GPM6B glycoprotein M6B
GPR161 G protein-coupled receptor 161
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HES1 hes family bHLH transcription factor 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
LOXL2 lysyl oxidase-like 2
LYPD1 LY6/PLAUR domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1B microtubule-associated protein 1B
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MYO10 myosin X
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLAU plasminogen activator, urokinase
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
RANBP2 RAN binding protein 2
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRGN serglycin
SST somatostatin
TMEM45A transmembrane protein 45A
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ABLIM1 actin binding LIM protein 1
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APLP2 amyloid beta (A4) precursor-like protein 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATPIF1 ATPase inhibitory factor 1
AURKA aurora kinase A
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD5 C2 calcium-dependent domain containing 5
C7 complement component 7
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CHEK2 checkpoint kinase 2
CHPT1 choline phosphotransferase 1
CHRDL1 chordin-like 1
COX17 COX17 cytochrome c oxidase copper chaperone
CXCL12 chemokine (C-X-C motif) ligand 12
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
ECT2 epithelial cell transforming 2
EMP2 epithelial membrane protein 2
ESR1 estrogen receptor 1
ETFB electron-transfer-flavoprotein, beta polypeptide
EVL Enah/Vasp-like
FAM111A family with sequence similarity 111, member A
FAM162A family with sequence similarity 162, member A
FAM63A family with sequence similarity 63, member A
FANCI Fanconi anemia, complementation group I
FLNB filamin B, beta
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GREB1 growth regulation by estrogen in breast cancer 1
GTF2H5 general transcription factor IIH, polypeptide 5
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST3H2A histone cluster 3, H2a
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNMT histamine N-methyltransferase
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ITPK1 inositol-tetrakisphosphate 1-kinase
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LXN latexin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MEGF9 multiple EGF-like-domains 9
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MGST2 microsomal glutathione S-transferase 2
MKI67 marker of proliferation Ki-67
MPC2 mitochondrial pyruvate carrier 2
MUC1 mucin 1, cell surface associated
MYCBP MYC binding protein
NBN nibrin
NCAPH non-SMC condensin I complex, subunit H
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
NUP210 nucleoporin 210kDa
OLFM1 olfactomedin 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTTG1 pituitary tumor-transforming 1
RBBP7 retinoblastoma binding protein 7
RBM47 RNA binding motif protein 47
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SEPHS1 selenophosphate synthetase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SRSF1 serine/arginine-rich splicing factor 1
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TSPAN6 tetraspanin 6
TTK TTK protein kinase
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VRK1 vaccinia related kinase 1
WDR61 WD repeat domain 61
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XBP1 X-box binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)
ZWINT ZW10 interacting kinetochore protein