BRD-K95976153_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K95976153_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ALDOB aldolase B, fructose-bisphosphate
ARG2 arginase 2
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRP C-reactive protein, pentraxin-related
DENND1B DENN/MADD domain containing 1B
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPAS1 endothelial PAS domain protein 1
FAM69A family with sequence similarity 69, member A
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FOS FBJ murine osteosarcoma viral oncogene homolog
FTH1 ferritin, heavy polypeptide 1
FZD10 frizzled class receptor 10
GDF15 growth differentiation factor 15
GRB7 growth factor receptor-bound protein 7
HIST1H2BG histone cluster 1, H2bg
INSIG1 insulin induced gene 1
ISOC1 isochorismatase domain containing 1
KLF11 Kruppel-like factor 11
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
MCAM melanoma cell adhesion molecule
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
ORC1 origin recognition complex, subunit 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTN pleiotrophin
RHOB ras homolog family member B
RNASE6 ribonuclease, RNase A family, k6
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SPON2 spondin 2, extracellular matrix protein
TFPI2 tissue factor pathway inhibitor 2
VCAN versican
VEGFA vascular endothelial growth factor A
VNN1 vanin 1

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ANXA3 annexin A3
BST2 bone marrow stromal cell antigen 2
CCL19 chemokine (C-C motif) ligand 19
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CPVL carboxypeptidase, vitellogenic-like
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HACD2 3-hydroxyacyl-CoA dehydratase 2
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HOXC6 homeobox C6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IQGAP1 IQ motif containing GTPase activating protein 1
LEF1 lymphoid enhancer-binding factor 1
LOXL1 lysyl oxidase-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MPZL1 myelin protein zero-like 1
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NRN1 neuritin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRR7 proline rich 7 (synaptic)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
SLIT2 slit homolog 2 (Drosophila)
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TSPYL5 TSPY-like 5