BRD-K95785537_PP 2_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K95785537_PP 2_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD163 CD163 molecule
CDC27 cell division cycle 27
CDK14 cyclin-dependent kinase 14
CLDN4 claudin 4
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FHL1 four and a half LIM domains 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GYPC glycophorin C (Gerbich blood group)
HIST1H4C histone cluster 1, H4c
HLA-DMB major histocompatibility complex, class II, DM beta
IFI16 interferon, gamma-inducible protein 16
ILF3 interleukin enhancer binding factor 3, 90kDa
IQGAP1 IQ motif containing GTPase activating protein 1
ITGB6 integrin, beta 6
KRT18 keratin 18, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NRGN neurogranin (protein kinase C substrate, RC3)
OPN3 opsin 3
PDIA4 protein disulfide isomerase family A, member 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PROM1 prominin 1
PRRC2C proline-rich coiled-coil 2C
RPL28 ribosomal protein L28
SCRN1 secernin 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TOP1 topoisomerase (DNA) I

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BMP2 bone morphogenetic protein 2
CA2 carbonic anhydrase II
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHL1 cell adhesion molecule L1-like
CKB creatine kinase, brain
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CTH cystathionine gamma-lyase
CYCS cytochrome c, somatic
EGR3 early growth response 3
ELN elastin
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FASTKD5 FAST kinase domains 5
FRZB frizzled-related protein
GCH1 GTP cyclohydrolase 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ISG15 ISG15 ubiquitin-like modifier
KLF4 Kruppel-like factor 4 (gut)
MMP10 matrix metallopeptidase 10
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEBL nebulette
PDZD2 PDZ domain containing 2
PLLP plasmolipin
RBP4 retinol binding protein 4, plasma
REG1A regenerating islet-derived 1 alpha
S100P S100 calcium binding protein P
SC5D sterol-C5-desaturase
SCG2 secretogranin II
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SST somatostatin
TACC2 transforming, acidic coiled-coil containing protein 2
TFRC transferrin receptor
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
WBP5 WW domain binding protein 5
ZW10 zw10 kinetochore protein