BRD-K95785537_PP 2_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K95785537_PP 2_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
CENPE centromere protein E, 312kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COLEC12 collectin sub-family member 12
CRYAB crystallin, alpha B
CST3 cystatin C
CSTA cystatin A (stefin A)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DSC3 desmocollin 3
DSG3 desmoglein 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GOLGA8A golgin A8 family, member A
GSTP1 glutathione S-transferase pi 1
IFITM1 interferon induced transmembrane protein 1
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LY6D lymphocyte antigen 6 complex, locus D
MBNL2 muscleblind-like splicing regulator 2
MMP12 matrix metallopeptidase 12
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PDZK1IP1 PDZK1 interacting protein 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLPI secretory leukocyte peptidase inhibitor
SOCS2 suppressor of cytokine signaling 2
SPRR1B small proline-rich protein 1B
SRGN serglycin
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TP63 tumor protein p63
TPD52L1 tumor protein D52-like 1
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AKAP12 A kinase (PRKA) anchor protein 12
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
C3ORF52 chromosome 3 open reading frame 52
CAB39 calcium binding protein 39
CCND1 cyclin D1
CCND2 cyclin D2
CD69 CD69 molecule
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTGF connective tissue growth factor
CXCL3 chemokine (C-X-C motif) ligand 3
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
F12 coagulation factor XII (Hageman factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBXL12 F-box and leucine-rich repeat protein 12
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
NOP16 NOP16 nucleolar protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLK3 polo-like kinase 3
PODXL podocalyxin-like
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROM1 prominin 1
PRR7 proline rich 7 (synaptic)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RPP38 ribonuclease P/MRP 38kDa subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH2B3 SH2B adaptor protein 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SYNJ2 synaptojanin 2
THBS1 thrombospondin 1
TRAPPC3 trafficking protein particle complex 3
TSC22D2 TSC22 domain family, member 2
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing