BRD-K95435023_PHA-665752_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K95435023_PHA-665752_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACA acetyl-CoA carboxylase alpha
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
AHNAK AHNAK nucleoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ARG2 arginase 2
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EHD3 EH-domain containing 3
ELOVL6 ELOVL fatty acid elongase 6
EPS8L2 EPS8-like 2
FBN2 fibrillin 2
FGFR3 fibroblast growth factor receptor 3
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAST4 microtubule associated serine/threonine kinase family member 4
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NKX3-1 NK3 homeobox 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PDGFC platelet derived growth factor C
PPAP2A phosphatidic acid phosphatase type 2A
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRNP prion protein
PYCARD PYD and CARD domain containing
RAB40B RAB40B, member RAS oncogene family
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RRBP1 ribosome binding protein 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC22A18 solute carrier family 22, member 18
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPAG4 sperm associated antigen 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC1 stanniocalcin 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TFF1 trefoil factor 1
TMEM97 transmembrane protein 97
TPM2 tropomyosin 2 (beta)
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1
VLDLR very low density lipoprotein receptor
VNN1 vanin 1
WFDC1 WAP four-disulfide core domain 1
YPEL5 yippee-like 5 (Drosophila)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CALR calreticulin
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIAPIN1 cytokine induced apoptosis inhibitor 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CXCL14 chemokine (C-X-C motif) ligand 14
DBF4 DBF4 zinc finger
DCN decorin
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
EREG epiregulin
FCGBP Fc fragment of IgG binding protein
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HRH1 histamine receptor H1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MSLN mesothelin
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
OXA1L oxidase (cytochrome c) assembly 1-like
PBK PDZ binding kinase
PDE4B phosphodiesterase 4B, cAMP-specific
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PON3 paraoxonase 3
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTTG1 pituitary tumor-transforming 1
RBP1 retinol binding protein 1, cellular
RFC3 replication factor C (activator 1) 3, 38kDa
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRM2 ribonucleotide reductase M2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCG2 secretogranin II
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SMAD1 SMAD family member 1
SMC4 structural maintenance of chromosomes 4
SRM spermidine synthase
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein