BRD-K95435023_PHA-665752_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K95435023_PHA-665752_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACAT2 acetyl-CoA acetyltransferase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAD aminolevulinate dehydratase
ANPEP alanyl (membrane) aminopeptidase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
BEX1 brain expressed, X-linked 1
BLVRB biliverdin reductase B
C1ORF115 chromosome 1 open reading frame 115
C3ORF14 chromosome 3 open reading frame 14
C5 complement component 5
CAT catalase
CCNG2 cyclin G2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CFB complement factor B
CRABP2 cellular retinoic acid binding protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DHCR7 7-dehydrocholesterol reductase
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
EFS embryonal Fyn-associated substrate
EHD3 EH-domain containing 3
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAM63A family with sequence similarity 63, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
GM2A GM2 ganglioside activator
GOLGA8H golgin A8 family, member H
GPER1 G protein-coupled estrogen receptor 1
GPM6B glycoprotein M6B
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HBB hemoglobin, beta
HDAC6 histone deacetylase 6
HECA headcase homolog (Drosophila)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRF9 interferon regulatory factor 9
KDM5D lysine (K)-specific demethylase 5D
KYNU kynureninase
LMO2 LIM domain only 2 (rhombotin-like 1)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY6D lymphocyte antigen 6 complex, locus D
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MYO10 myosin X
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMRK1 nicotinamide riboside kinase 1
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
OPN3 opsin 3
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PHYH phytanoyl-CoA 2-hydroxylase
PPL periplakin
PROM1 prominin 1
PYCARD PYD and CARD domain containing
PYGL phosphorylase, glycogen, liver
RABGAP1L RAB GTPase activating protein 1-like
RPS11 ribosomal protein S11
S100A8 S100 calcium binding protein A8
SESN1 sestrin 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNN stannin
SOX11 SRY (sex determining region Y)-box 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SREBF1 sterol regulatory element binding transcription factor 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TSPYL5 TSPY-like 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WWOX WW domain containing oxidoreductase
XYLT1 xylosyltransferase I
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM9 ADAM metallopeptidase domain 9
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDOA aldolase A, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BYSL bystin-like
C1QBP complement component 1, q subcomponent binding protein
CD9 CD9 molecule
CEMIP cell migration inducing protein, hyaluronan binding
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
COMP cartilage oligomeric matrix protein
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EBNA1BP2 EBNA1 binding protein 2
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EREG epiregulin
FAM60A family with sequence similarity 60, member A
FAT1 FAT atypical cadherin 1
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GYG1 glycogenin 1
HES1 hes family bHLH transcription factor 1
HOPX HOP homeobox
HOXB7 homeobox B7
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
JAG1 jagged 1
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LIF leukemia inhibitory factor
LOXL2 lysyl oxidase-like 2
LUM lumican
LYPLA1 lysophospholipase I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MINA MYC induced nuclear antigen
MLEC malectin
MMP12 matrix metallopeptidase 12
MRPS2 mitochondrial ribosomal protein S2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NNMT nicotinamide N-methyltransferase
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
PA2G4 proliferation-associated 2G4, 38kDa
PAK1IP1 PAK1 interacting protein 1
PDLIM3 PDZ and LIM domain 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PLA1A phospholipase A1 member A
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
PRMT1 protein arginine methyltransferase 1
PRNP prion protein
RBPMS RNA binding protein with multiple splicing
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SDF2L1 stromal cell-derived factor 2-like 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPTBN1 spectrin, beta, non-erythrocytic 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF3 trefoil factor 3 (intestinal)
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing