BRD-K95435023_PHA-665752_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K95435023_PHA-665752_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADRB2 adrenoceptor beta 2, surface
ALDOC aldolase C, fructose-bisphosphate
C14ORF1 chromosome 14 open reading frame 1
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
DENND2D DENN/MADD domain containing 2D
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ETNPPL ethanolamine-phosphate phospho-lyase
EVL Enah/Vasp-like
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGFR3 fibroblast growth factor receptor 3
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOLH1B folate hydrolase 1B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
LDLR low density lipoprotein receptor
LGALS2 lectin, galactoside-binding, soluble, 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAL mal, T-cell differentiation protein
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
NEBL nebulette
NEFL neurofilament, light polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NKG7 natural killer cell granule protein 7
NUPR1 nuclear protein, transcriptional regulator, 1
PLK2 polo-like kinase 2
PXDN peroxidasin
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
S100A10 S100 calcium binding protein A10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
TARP TCR gamma alternate reading frame protein
TJP2 tight junction protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CD200 CD200 molecule
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
ELANE elastase, neutrophil expressed
FAM129A family with sequence similarity 129, member A
IL1R2 interleukin 1 receptor, type II
LTF lactotransferrin
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NAMPT nicotinamide phosphoribosyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDE4B phosphodiesterase 4B, cAMP-specific
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PROM1 prominin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
UGDH UDP-glucose 6-dehydrogenase