BRD-K95435023_PHA-665752_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K95435023_PHA-665752_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA4 annexin A4
ATF3 activating transcription factor 3
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA4 chloride channel accessory 4
COL11A1 collagen, type XI, alpha 1
CRYAB crystallin, alpha B
CTSO cathepsin O
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
EFNA1 ephrin-A1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP1 fatty acid binding protein 1, liver
FMO3 flavin containing monooxygenase 3
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTT1 glutathione S-transferase theta 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HNMT histamine N-methyltransferase
HOOK2 hook microtubule-tethering protein 2
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT23 keratin 23, type I
LAMP2 lysosomal-associated membrane protein 2
MATN2 matrilin 2
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MSRB1 methionine sulfoxide reductase B1
MUC1 mucin 1, cell surface associated
MVP major vault protein
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PFKL phosphofructokinase, liver
PIR pirin (iron-binding nuclear protein)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRUNE2 prune homolog 2 (Drosophila)
QKI QKI, KH domain containing, RNA binding
RHOBTB3 Rho-related BTB domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SELENBP1 selenium binding protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SKAP2 src kinase associated phosphoprotein 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX2 SRY (sex determining region Y)-box 2
SPATA20 spermatogenesis associated 20
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSC2 tuberous sclerosis 2
TTC3 tetratricopeptide repeat domain 3
TUBB2B tubulin, beta 2B class IIb
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
YPEL5 yippee-like 5 (Drosophila)
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ACTN1 actinin, alpha 1
AQP3 aquaporin 3 (Gill blood group)
BASP1 brain abundant, membrane attached signal protein 1
CCL19 chemokine (C-C motif) ligand 19
CCND1 cyclin D1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
COL4A2 collagen, type IV, alpha 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GZMK granzyme K (granzyme 3; tryptase II)
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
KCTD12 potassium channel tetramerization domain containing 12
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MAP7 microtubule-associated protein 7
MCM10 minichromosome maintenance complex component 10
MCM7 minichromosome maintenance complex component 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBL1 neuroblastoma 1, DAN family BMP antagonist
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4D phosphodiesterase 4D, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RFC2 replication factor C (activator 1) 2, 40kDa
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAGP small cell adhesion glycoprotein
SMCO4 single-pass membrane protein with coiled-coil domains 4
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TSPYL5 TSPY-like 5
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1