BRD-K95196255_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K95196255_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD4 bromodomain containing 4
BTG1 B-cell translocation gene 1, anti-proliferative
C1QB complement component 1, q subcomponent, B chain
CA1 carbonic anhydrase I
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF5A eukaryotic translation initiation factor 5A
EPHA3 EPH receptor A3
F3 coagulation factor III (thromboplastin, tissue factor)
FAM107A family with sequence similarity 107, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IGKC immunoglobulin kappa constant
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
LHFP lipoma HMGIC fusion partner
LRRC17 leucine rich repeat containing 17
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP5 microfibrillar associated protein 5
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PER1 period circadian clock 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAU plasminogen activator, urokinase
PMEPA1 prostate transmembrane protein, androgen induced 1
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
S100P S100 calcium binding protein P
SCG5 secretogranin V
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG4 sperm associated antigen 4
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
STAB1 stabilin 1
SYT1 synaptotagmin I
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
ZBTB16 zinc finger and BTB domain containing 16
ZIC1 Zic family member 1
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARMCX6 armadillo repeat containing, X-linked 6
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CD200 CD200 molecule
CDC20 cell division cycle 20
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
FXYD2 FXYD domain containing ion transport regulator 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF20A kinesin family member 20A
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP7 microtubule-associated protein 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
RELN reelin
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SRSF6 serine/arginine-rich splicing factor 6
STMN1 stathmin 1
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
UGCG UDP-glucose ceramide glucosyltransferase
XBP1 X-box binding protein 1