BRD-K95196255_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K95196255_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
ARG1 arginase 1
BBX bobby sox homolog (Drosophila)
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNE2 cyclin E2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFH complement factor H
COL9A3 collagen, type IX, alpha 3
CRLF1 cytokine receptor-like factor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDHD2 DDHD domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP3 dual specificity phosphatase 3
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERO1L ERO1-like (S. cerevisiae)
FAM162A family with sequence similarity 162, member A
FGFR3 fibroblast growth factor receptor 3
FKBP5 FK506 binding protein 5
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GOLGA8A golgin A8 family, member A
GPI glucose-6-phosphate isomerase
GPM6B glycoprotein M6B
HAL histidine ammonia-lyase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPB11 heat shock protein family B (small), member 11
IFI27 interferon, alpha-inducible protein 27
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K1 mitogen-activated protein kinase kinase 1
MEF2A myocyte enhancer factor 2A
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLLP plasmolipin
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRDX4 peroxiredoxin 4
RBM38 RNA binding motif protein 38
RNMT RNA (guanine-7-) methyltransferase
RORA RAR-related orphan receptor A
S100P S100 calcium binding protein P
SARAF store-operated calcium entry-associated regulatory factor
SAT1 spermidine/spermine N1-acetyltransferase 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPAG4 sperm associated antigen 4
STC2 stanniocalcin 2
TMEM45A transmembrane protein 45A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TSC22D3 TSC22 domain family, member 3
TSPYL2 TSPY-like 2
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACTN4 actinin, alpha 4
AMDHD2 amidohydrolase domain containing 2
APP amyloid beta (A4) precursor protein
AURKA aurora kinase A
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD24 CD24 molecule
CDC25B cell division cycle 25B
CEP55 centrosomal protein 55kDa
COG4 component of oligomeric golgi complex 4
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EDN1 endothelin 1
FBLN1 fibulin 1
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HOXA10 homeobox A10
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IRS1 insulin receptor substrate 1
MMP7 matrix metallopeptidase 7
MRPS12 mitochondrial ribosomal protein S12
MYOF myoferlin
NMT2 N-myristoyltransferase 2
NPM3 nucleophosmin/nucleoplasmin 3
NRG1 neuregulin 1
NRP1 neuropilin 1
PDGFD platelet derived growth factor D
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
RGS10 regulator of G-protein signaling 10
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STON1 stonin 1
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOP2A topoisomerase (DNA) II alpha 170kDa