BRD-K94832621_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K94832621_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BACE2 beta-site APP-cleaving enzyme 2
CA12 carbonic anhydrase XII
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
DENND1B DENN/MADD domain containing 1B
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KCTD12 potassium channel tetramerization domain containing 12
LDLR low density lipoprotein receptor
MME membrane metallo-endopeptidase
MTUS1 microtubule associated tumor suppressor 1
NEB nebulin
PEG3 paternally expressed 3
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTPRE protein tyrosine phosphatase, receptor type, E
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SQLE squalene epoxidase
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMCC1 transmembrane and coiled-coil domain family 1
TWIST1 twist family bHLH transcription factor 1
WNT5A wingless-type MMTV integration site family, member 5A
XAF1 XIAP associated factor 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADAM10 ADAM metallopeptidase domain 10
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
AQP3 aquaporin 3 (Gill blood group)
C8ORF4 chromosome 8 open reading frame 4
CALD1 caldesmon 1
CD59 CD59 molecule, complement regulatory protein
CLIC4 chloride intracellular channel 4
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CYR61 cysteine-rich, angiogenic inducer, 61
FERMT2 fermitin family member 2
FHL1 four and a half LIM domains 1
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
MAGEA3 melanoma antigen family A3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCSK1 proprotein convertase subtilisin/kexin type 1
S100P S100 calcium binding protein P
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORBS1 sorbin and SH3 domain containing 1
SORD sorbitol dehydrogenase
STOM stomatin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM47 transmembrane protein 47
TOB1 transducer of ERBB2, 1