BRD-K94325918_-666_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K94325918_-666_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL6 B-cell CLL/lymphoma 6
BTG2 BTG family, member 2
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCA2 chloride channel accessory 2
CTSK cathepsin K
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
EZR ezrin
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPAS2 neuronal PAS domain protein 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PI3 peptidase inhibitor 3, skin-derived
PLAUR plasminogen activator, urokinase receptor
PLXNA1 plexin A1
PSAT1 phosphoserine aminotransferase 1
PTGES prostaglandin E synthase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RHOB ras homolog family member B
RND3 Rho family GTPase 3
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC44A4 solute carrier family 44, member 4
SOX9 SRY (sex determining region Y)-box 9
TFRC transferrin receptor
THBS1 thrombospondin 1
TRIB3 tribbles pseudokinase 3
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
ANXA6 annexin A6
CCL5 chemokine (C-C motif) ligand 5
CD200 CD200 molecule
CD320 CD320 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CPM carboxypeptidase M
CSRP2 cysteine and glycine-rich protein 2
CTSB cathepsin B
HIST1H2BG histone cluster 1, H2bg
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
LGALS1 lectin, galactoside-binding, soluble, 1
LPL lipoprotein lipase
LYRM1 LYR motif containing 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
MRPL23 mitochondrial ribosomal protein L23
MRPS16 mitochondrial ribosomal protein S16
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NELL2 NEL-like 2 (chicken)
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFML2A olfactomedin-like 2A
PHYH phytanoyl-CoA 2-hydroxylase
PLK1 polo-like kinase 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYNM synemin, intermediate filament protein
TNS1 tensin 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28