BRD-K94325918_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K94325918_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATF3 activating transcription factor 3
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CLU clusterin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
FAM46A family with sequence similarity 46, member A
FEM1C fem-1 homolog c (C. elegans)
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KYNU kynureninase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NAMPT nicotinamide phosphoribosyltransferase
NKX3-1 NK3 homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
OPN3 opsin 3
OSER1 oxidative stress responsive serine-rich 1
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTHLH parathyroid hormone-like hormone
RIT1 Ras-like without CAAX 1
S100P S100 calcium binding protein P
SCYL3 SCY1-like 3 (S. cerevisiae)
SERTAD2 SERTA domain containing 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPATA2 spermatogenesis associated 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNPO1 transportin 1
TPD52L1 tumor protein D52-like 1
TRIB1 tribbles pseudokinase 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
ZYX zyxin

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
C7 complement component 7
CD200 CD200 molecule
COL3A1 collagen, type III, alpha 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP4 dipeptidyl-peptidase 4
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR3 fibroblast growth factor receptor 3
FGL1 fibrinogen-like 1
FXYD2 FXYD domain containing ion transport regulator 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRK5 G protein-coupled receptor kinase 5
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM3 interferon induced transmembrane protein 3
IL1R1 interleukin 1 receptor, type I
IL33 interleukin 33
ISG15 ISG15 ubiquitin-like modifier
JAM3 junctional adhesion molecule 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MYRF myelin regulatory factor
NR2F1 nuclear receptor subfamily 2, group F, member 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBLD phenazine biosynthesis-like protein domain containing
PEG3 paternally expressed 3
PRSS2 protease, serine, 2 (trypsin 2)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXDN peroxidasin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REG1B regenerating islet-derived 1 beta
RGS4 regulator of G-protein signaling 4
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SHB Src homology 2 domain containing adaptor protein B
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPINK1 serine peptidase inhibitor, Kazal type 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TM4SF4 transmembrane 4 L six family member 4
TPPP3 tubulin polymerization-promoting protein family member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican
VIM vimentin