BRD-K94176593_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-K94176593_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARL4C ADP-ribosylation factor-like 4C
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASS1 argininosuccinate synthase 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BEX1 brain expressed, X-linked 1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C10ORF10 chromosome 10 open reading frame 10
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCR2 chemokine (C-C motif) receptor 2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD93 CD93 molecule
CES2 carboxylesterase 2
CFB complement factor B
COG7 component of oligomeric golgi complex 7
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
DAPK1 death-associated protein kinase 1
DCAF10 DDB1 and CUL4 associated factor 10
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPP4 dipeptidyl-peptidase 4
DPYD dihydropyrimidine dehydrogenase
EHF ets homologous factor
EPAS1 endothelial PAS domain protein 1
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GMPR guanosine monophosphate reductase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H3H histone cluster 1, H3h
HOXD1 homeobox D1
INSM1 insulinoma-associated 1
INTS8 integrator complex subunit 8
ITGB4 integrin, beta 4
JAG1 jagged 1
JAG2 jagged 2
JUP junction plakoglobin
KCTD12 potassium channel tetramerization domain containing 12
KIF14 kinesin family member 14
KLF4 Kruppel-like factor 4 (gut)
LAMP3 lysosomal-associated membrane protein 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
NELL2 NEL-like 2 (chicken)
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFD platelet derived growth factor D
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLK1 polo-like kinase 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTK2B protein tyrosine kinase 2 beta
PXN paxillin
PYCARD PYD and CARD domain containing
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCAN2 regulator of calcineurin 2
RGS5 regulator of G-protein signaling 5
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIRPA signal-regulatory protein alpha
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOCS2 suppressor of cytokine signaling 2
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SUSD4 sushi domain containing 4
SYBU syntabulin (syntaxin-interacting)
SYNPO synaptopodin
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TPBG trophoblast glycoprotein
TRAPPC6A trafficking protein particle complex 6A
TSPAN12 tetraspanin 12
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AK2 adenylate kinase 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA6 annexin A6
ASPH aspartate beta-hydroxylase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAG2 BCL2-associated athanogene 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BST2 bone marrow stromal cell antigen 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHPT1 choline phosphotransferase 1
COL14A1 collagen, type XIV, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFS embryonal Fyn-associated substrate
EGR3 early growth response 3
ENO1 enolase 1, (alpha)
ETV1 ets variant 1
FBN1 fibrillin 1
FN1 fibronectin 1
GSTT1 glutathione S-transferase theta 1
HBB hemoglobin, beta
HMGA2 high mobility group AT-hook 2
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOMER1 homer scaffolding protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
ITGB5 integrin, beta 5
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
LTBP3 latent transforming growth factor beta binding protein 3
MFAP2 microfibrillar-associated protein 2
MSRB2 methionine sulfoxide reductase B2
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCBP2 poly(rC) binding protein 2
PDIA6 protein disulfide isomerase family A, member 6
PEBP1 phosphatidylethanolamine binding protein 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRDX2 peroxiredoxin 2
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTPRM protein tyrosine phosphatase, receptor type, M
RAB31 RAB31, member RAS oncogene family
RBMS1 RNA binding motif, single stranded interacting protein 1
RCAN1 regulator of calcineurin 1
RGS4 regulator of G-protein signaling 4
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC43A3 solute carrier family 43, member 3
STC2 stanniocalcin 2
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPM1 tropomyosin 1 (alpha)
VCAN versican
WIF1 WNT inhibitory factor 1