BRD-K94176593_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K94176593_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ARHGAP29 Rho GTPase activating protein 29
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
AURKA aurora kinase A
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD40 CD40 molecule, TNF receptor superfamily member 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPA3 carboxypeptidase A3 (mast cell)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DLK1 delta-like 1 homolog (Drosophila)
DMXL2 Dmx-like 2
DPYSL3 dihydropyrimidinase-like 3
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FST follistatin
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOMER3 homer scaffolding protein 3
IDO1 indoleamine 2,3-dioxygenase 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGLV3-19 immunoglobulin lambda variable 3-19
IL7R interleukin 7 receptor
ITGB5 integrin, beta 5
JAG1 jagged 1
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LMO3 LIM domain only 3 (rhombotin-like 2)
MXRA7 matrix-remodelling associated 7
NELL2 NEL-like 2 (chicken)
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NUCB2 nucleobindin 2
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCLO piccolo presynaptic cytomatrix protein
PDGFC platelet derived growth factor C
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLVAP plasmalemma vesicle associated protein
PSRC1 proline/serine-rich coiled-coil 1
PTPRC protein tyrosine phosphatase, receptor type, C
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRED2 sprouty-related, EVH1 domain containing 2
TDO2 tryptophan 2,3-dioxygenase
TIMP1 TIMP metallopeptidase inhibitor 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRHDE thyrotropin-releasing hormone degrading enzyme
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
CD59 CD59 molecule, complement regulatory protein
CDK1 cyclin-dependent kinase 1
CDK19 cyclin-dependent kinase 19
CELF2 CUGBP, Elav-like family member 2
CHPT1 choline phosphotransferase 1
COG5 component of oligomeric golgi complex 5
CTSB cathepsin B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAPP E2F-associated phosphoprotein
ENO2 enolase 2 (gamma, neuronal)
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FAM57A family with sequence similarity 57, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOXO3 forkhead box O3
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
LARP4B La ribonucleoprotein domain family, member 4B
MBP myelin basic protein
MELK maternal embryonic leucine zipper kinase
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOTCH2 notch 2
NUP98 nucleoporin 98kDa
OPN3 opsin 3
PRKCD protein kinase C, delta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
RNASE4 ribonuclease, RNase A family, 4
RNMT RNA (guanine-7-) methyltransferase
S100A11 S100 calcium binding protein A11
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
TACC1 transforming, acidic coiled-coil containing protein 1
TBX2 T-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBA1A tubulin, alpha 1a
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNG uracil-DNA glycosylase
WEE1 WEE1 G2 checkpoint kinase