BRD-K94176593_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K94176593_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADD3 adducin 3 (gamma)
AURKA aurora kinase A
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CXCL12 chemokine (C-X-C motif) ligand 12
KIF20A kinesin family member 20A
MXRA5 matrix-remodelling associated 5
NRIP1 nuclear receptor interacting protein 1
PDE4DIP phosphodiesterase 4D interacting protein
PRTN3 proteinase 3
S100A9 S100 calcium binding protein A9
SELENBP1 selenium binding protein 1
SLPI secretory leukocyte peptidase inhibitor
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADGRL2 adhesion G protein-coupled receptor L2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
BMP2 bone morphogenetic protein 2
C3ORF14 chromosome 3 open reading frame 14
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CIAPIN1 cytokine induced apoptosis inhibitor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DUOX2 dual oxidase 2
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GATA6 GATA binding protein 6
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GMDS GDP-mannose 4,6-dehydratase
GPX2 glutathione peroxidase 2
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LYZ lysozyme
MCAM melanoma cell adhesion molecule
MYC v-myc avian myelocytomatosis viral oncogene homolog
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PPARG peroxisome proliferator-activated receptor gamma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RNPS1 RNA binding protein S1, serine-rich domain
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SMAD3 SMAD family member 3
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFF1 trefoil factor 1
TFRC transferrin receptor
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TOX3 TOX high mobility group box family member 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa