BRD-K94176593_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K94176593_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ASRGL1 asparaginase like 1
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLIC4 chloride intracellular channel 4
CPE carboxypeptidase E
CREB1 cAMP responsive element binding protein 1
CRYAB crystallin, alpha B
CX3CL1 chemokine (C-X3-C motif) ligand 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
EIF5A eukaryotic translation initiation factor 5A
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IFI6 interferon, alpha-inducible protein 6
ITM2C integral membrane protein 2C
LGALS4 lectin, galactoside-binding, soluble, 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
PRDX2 peroxiredoxin 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB40B RAB40B, member RAS oncogene family
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SFRP4 secreted frizzled-related protein 4
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SOX2 SRY (sex determining region Y)-box 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
THBS2 thrombospondin 2
TPD52L1 tumor protein D52-like 1
TRIM22 tripartite motif containing 22
TUBB2B tubulin, beta 2B class IIb
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
BIRC2 baculoviral IAP repeat containing 2
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CDCA4 cell division cycle associated 4
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIB1 calcium and integrin binding 1 (calmyrin)
CLEC11A C-type lectin domain family 11, member A
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRC5A G protein-coupled receptor, class C, group 5, member A
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOK MOK protein kinase
MTF2 metal response element binding transcription factor 2
NET1 neuroepithelial cell transforming 1
PCTP phosphatidylcholine transfer protein
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PMEPA1 prostate transmembrane protein, androgen induced 1
POPDC3 popeye domain containing 3
PRDX1 peroxiredoxin 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A9 S100 calcium binding protein A9
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPRY2 sprouty homolog 2 (Drosophila)
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TSC22D2 TSC22 domain family, member 2
UPP1 uridine phosphorylase 1