BRD-K94173926_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K94173926_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADGRG2 adhesion G protein-coupled receptor G2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
BGN biglycan
BTG1 B-cell translocation gene 1, anti-proliferative
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL15A1 collagen, type XV, alpha 1
COMP cartilage oligomeric matrix protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GFPT1 glutamine--fructose-6-phosphate transaminase 1
HMOX1 heme oxygenase 1
IFRD1 interferon-related developmental regulator 1
KIF5C kinesin family member 5C
KLF4 Kruppel-like factor 4 (gut)
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MMP13 matrix metallopeptidase 13
NCAM1 neural cell adhesion molecule 1
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PEG3 paternally expressed 3
PSAT1 phosphoserine aminotransferase 1
PTPRD protein tyrosine phosphatase, receptor type, D
RAP1GAP RAP1 GTPase activating protein
RGS1 regulator of G-protein signaling 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC5 serine incorporator 5
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TYROBP TYRO protein tyrosine kinase binding protein
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AGR2 anterior gradient 2
ASF1B anti-silencing function 1B histone chaperone
BAG3 BCL2-associated athanogene 3
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
EBP emopamil binding protein (sterol isomerase)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
ITGB1BP1 integrin beta 1 binding protein 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPH non-SMC condensin I complex, subunit H
NR2F2 nuclear receptor subfamily 2, group F, member 2
OXA1L oxidase (cytochrome c) assembly 1-like
PCNA proliferating cell nuclear antigen
PKM pyruvate kinase, muscle
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RRM2 ribonucleotide reductase M2
SFN stratifin
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TK1 thymidine kinase 1, soluble
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S