BRD-K94127894_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-K94127894_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASS1 argininosuccinate synthase 1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CP ceruloplasmin (ferroxidase)
CTSB cathepsin B
CXCL5 chemokine (C-X-C motif) ligand 5
EFS embryonal Fyn-associated substrate
HAPLN1 hyaluronan and proteoglycan link protein 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KIAA0226L KIAA0226-like
LGALS8 lectin, galactoside-binding, soluble, 8
MKNK1 MAP kinase interacting serine/threonine kinase 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
NEFH neurofilament, heavy polypeptide
NLRP2 NLR family, pyrin domain containing 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLSCR3 phospholipid scramblase 3
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCF4 transcription factor 4
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
TSPYL5 TSPY-like 5

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
F2RL1 coagulation factor II (thrombin) receptor-like 1
GUSBP11 glucuronidase, beta pseudogene 11
HHEX hematopoietically expressed homeobox
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MTERF3 mitochondrial transcription termination factor 3
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SMCO4 single-pass membrane protein with coiled-coil domains 4
TLR4 toll-like receptor 4
TMEM176B transmembrane protein 176B
VCAN versican