BRD-K94018295_STOCK2S-79598_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K94018295_STOCK2S-79598_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
CAV1 caveolin 1, caveolae protein, 22kDa
CBS cystathionine-beta-synthase
CES1 carboxylesterase 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CTSL cathepsin L
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
G6PD glucose-6-phosphate dehydrogenase
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GNAS GNAS complex locus
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MPZL2 myelin protein zero-like 2
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
PERP PERP, TP53 apoptosis effector
PGD phosphogluconate dehydrogenase
PHGDH phosphoglycerate dehydrogenase
PPAP2B phosphatidic acid phosphatase type 2B
PRUNE2 prune homolog 2 (Drosophila)
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STON1 stonin 1
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
VGLL1 vestigial-like family member 1
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ASRGL1 asparaginase like 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
B3GNT1
BAG3 BCL2-associated athanogene 3
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
C2CD5 C2 calcium-dependent domain containing 5
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSH cathepsin H
CYBA cytochrome b-245, alpha polypeptide
DCK deoxycytidine kinase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EED embryonic ectoderm development
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
FASTKD5 FAST kinase domains 5
GHR growth hormone receptor
GINS2 GINS complex subunit 2 (Psf2 homolog)
HEXIM1 hexamethylene bis-acetamide inducible 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MUC1 mucin 1, cell surface associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RBP1 retinol binding protein 1, cellular
RFC2 replication factor C (activator 1) 2, 40kDa
RGS4 regulator of G-protein signaling 4
SCGB2A2 secretoglobin, family 2A, member 2
SFPQ splicing factor proline/glutamine-rich
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
UBE2C ubiquitin-conjugating enzyme E2C