BRD-K94012289_OSI-027_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K94012289_OSI-027_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP1 aquaporin 1 (Colton blood group)
CCL20 chemokine (C-C motif) ligand 20
CST6 cystatin E/M
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DCLK1 doublecortin-like kinase 1
FAM129A family with sequence similarity 129, member A
FYN FYN proto-oncogene, Src family tyrosine kinase
GATA3 GATA binding protein 3
GRB7 growth factor receptor-bound protein 7
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IL6 interleukin 6
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LGALS1 lectin, galactoside-binding, soluble, 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAMLD1 mastermind-like domain containing 1
MGP matrix Gla protein
NEFL neurofilament, light polypeptide
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDGFC platelet derived growth factor C
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
RGS10 regulator of G-protein signaling 10
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RORA RAR-related orphan receptor A
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SESN1 sestrin 1
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
TSPAN4 tetraspanin 4

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDC25A cell division cycle 25A
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
DPYD dihydropyrimidine dehydrogenase
EIF5 eukaryotic translation initiation factor 5
EREG epiregulin
FOS FBJ murine osteosarcoma viral oncogene homolog
GPATCH8 G patch domain containing 8
HEPH hephaestin
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
JADE2 jade family PHD finger 2
MBP myelin basic protein
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLAC8 placenta-specific 8
PMM2 phosphomannomutase 2
PRKCI protein kinase C, iota
PXDN peroxidasin
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
TLR4 toll-like receptor 4
TRIM36 tripartite motif containing 36