BRD-K94012289_OSI-027_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-K94012289_OSI-027_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADIRF adipogenesis regulatory factor
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ADRB2 adrenoceptor beta 2, surface
AHNAK AHNAK nucleoprotein
ALCAM activated leukocyte cell adhesion molecule
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARMCX6 armadillo repeat containing, X-linked 6
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK7 cyclin-dependent kinase 7
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CIRBP cold inducible RNA binding protein
CLDN4 claudin 4
CST1 cystatin SN
CTSL cathepsin L
CYTH1 cytohesin 1
DARS aspartyl-tRNA synthetase
DCLK1 doublecortin-like kinase 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSG2 desmoglein 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ESR1 estrogen receptor 1
FNBP1 formin binding protein 1
FOXO3 forkhead box O3
FST follistatin
FXR1 fragile X mental retardation, autosomal homolog 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GMPR guanosine monophosphate reductase
GOLGA8A golgin A8 family, member A
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HNMT histamine N-methyltransferase
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
IFI27 interferon, alpha-inducible protein 27
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
JMJD1C jumonji domain containing 1C
KIAA0355 KIAA0355
KLHDC2 kelch domain containing 2
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LUC7L3 LUC7-like 3 (S. cerevisiae)
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MBNL2 muscleblind-like splicing regulator 2
MITF microphthalmia-associated transcription factor
MLPH melanophilin
MOAP1 modulator of apoptosis 1
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NCK2 NCK adaptor protein 2
NDRG1 N-myc downstream regulated 1
NMI N-myc (and STAT) interactor
NPIPB3 nuclear pore complex interacting protein family, member B3
NRIP1 nuclear receptor interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARP4 poly (ADP-ribose) polymerase family, member 4
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG3 paternally expressed 3
PLA2G16 phospholipase A2, group XVI
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
PSD3 pleckstrin and Sec7 domain containing 3
QARS glutaminyl-tRNA synthetase
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
REEP5 receptor accessory protein 5
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RPL36 ribosomal protein L36
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RSL1D1 ribosomal L1 domain containing 1
RSL24D1 ribosomal L24 domain containing 1
SCGB2A1 secretoglobin, family 2A, member 1
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SLC22A18 solute carrier family 22, member 18
SMAD3 SMAD family member 3
SNX2 sorting nexin 2
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYF2 SYF2 pre-mRNA-splicing factor
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TMC5 transmembrane channel-like 5
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TTC17 tetratricopeptide repeat domain 17
TXNIP thioredoxin interacting protein
WASL Wiskott-Aldrich syndrome-like
WDR45 WD repeat domain 45
XIST X inactive specific transcript (non-protein coding)
ZBED5 zinc finger, BED-type containing 5
ZNF217 zinc finger protein 217
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AK1 adenylate kinase 1
ALOX5 arachidonate 5-lipoxygenase
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATAD2 ATPase family, AAA domain containing 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
C20ORF24 chromosome 20 open reading frame 24
CALB2 calbindin 2
CALR calreticulin
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CKAP4 cytoskeleton-associated protein 4
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
COTL1 coactosin-like F-actin binding protein 1
CRELD2 cysteine-rich with EGF-like domains 2
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FKBP1A FK506 binding protein 1A, 12kDa
FKBP5 FK506 binding protein 5
FRZB frizzled-related protein
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLT1B golgi transport 1B
GPM6B glycoprotein M6B
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA1A heat shock 70kDa protein 1A
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JCHAIN joining chain of multimeric IgA and IgM
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT6B keratin 6B, type II
LBR lamin B receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
LRRC59 leucine rich repeat containing 59
LYZ lysozyme
MALT1 MALT1 paracaspase
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAM1 neural cell adhesion molecule 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP56 NOP56 ribonucleoprotein
NSFL1C NSFL1 (p97) cofactor (p47)
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PRKCB protein kinase C, beta
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGDS prostaglandin D2 synthase 21kDa (brain)
RACGAP1 Rac GTPase activating protein 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
STMN1 stathmin 1
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TMPO thymopoietin
TPSAB1 tryptase alpha/beta 1
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TRAPPC3 trafficking protein particle complex 3
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein