BRD-K94012289_OSI-027_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K94012289_OSI-027_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AMIGO2 adhesion molecule with Ig-like domain 2
ATF4 activating transcription factor 4
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
BASP1 brain abundant, membrane attached signal protein 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDK7 cyclin-dependent kinase 7
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIRBP cold inducible RNA binding protein
CST1 cystatin SN
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DUSP1 dual specificity phosphatase 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
FOXO3 forkhead box O3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
JUP junction plakoglobin
KLF5 Kruppel-like factor 5 (intestinal)
LETMD1 LETM1 domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MTSS1 metastasis suppressor 1
MVP major vault protein
MZF1 myeloid zinc finger 1
N4BP2L2 NEDD4 binding protein 2-like 2
NAP1L1 nucleosome assembly protein 1-like 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L1 nuclear factor, erythroid 2-like 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PGLS 6-phosphogluconolactonase
PLA1A phospholipase A1 member A
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPOX protoporphyrinogen oxidase
PRAME preferentially expressed antigen in melanoma
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RPL36 ribosomal protein L36
S100P S100 calcium binding protein P
SECISBP2L SECIS binding protein 2-like
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPDEF SAM pointed domain containing ETS transcription factor
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TUG1 taurine up-regulated 1 (non-protein coding)
VCAN versican
WDR45 WD repeat domain 45

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIRC5 baculoviral IAP repeat containing 5
C3 complement component 3
CALR calreticulin
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYCS cytochrome c, somatic
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFS embryonal Fyn-associated substrate
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFR3 fibroblast growth factor receptor 3
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HRASLS HRAS-like suppressor
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LAGE3 L antigen family, member 3
LBR lamin B receptor
LPL lipoprotein lipase
LTB lymphotoxin beta (TNF superfamily, member 3)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALT1 MALT1 paracaspase
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
PBK PDZ binding kinase
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PON3 paraoxonase 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SDF2L1 stromal cell-derived factor 2-like 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35B1 solute carrier family 35, member B1
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SMCO4 single-pass membrane protein with coiled-coil domains 4
SRM spermidine synthase
STMN1 stathmin 1
TCL1A T-cell leukemia/lymphoma 1A
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VTCN1 V-set domain containing T cell activation inhibitor 1
WBSCR22 Williams Beuren syndrome chromosome region 22
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WSB2 WD repeat and SOCS box containing 2
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein