BRD-K94012289_OSI-027_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K94012289_OSI-027_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABLIM1 actin binding LIM protein 1
ADIRF adipogenesis regulatory factor
ANXA6 annexin A6
ATM ATM serine/threonine kinase
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
C6ORF48 chromosome 6 open reading frame 48
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLDN4 claudin 4
COL9A3 collagen, type IX, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DSG2 desmoglein 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FKBP9 FK506 binding protein 9, 63 kDa
FOXO3 forkhead box O3
GRB7 growth factor receptor-bound protein 7
IFITM2 interferon induced transmembrane protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KAT6B K(lysine) acetyltransferase 6B
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMS1 LIM and senescent cell antigen-like domains 1
LXN latexin
MEG3 maternally expressed 3 (non-protein coding)
MMP9 matrix metallopeptidase 9
MPHOSPH8 M-phase phosphoprotein 8
MVP major vault protein
MXRA5 matrix-remodelling associated 5
NAP1L1 nucleosome assembly protein 1-like 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
OBSL1 obscurin-like 1
OSBPL1A oxysterol binding protein-like 1A
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PLAU plasminogen activator, urokinase
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRKCH protein kinase C, eta
RGS10 regulator of G-protein signaling 10
S100P S100 calcium binding protein P
SDC4 syndecan 4
SEPT6 septin 6
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STK10 serine/threonine kinase 10
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WASL Wiskott-Aldrich syndrome-like

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND3 cyclin D3
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXM1 forkhead box M1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLIPR1 GLI pathogenesis-related 1
GSTT1 glutathione S-transferase theta 1
HIPK1 homeodomain interacting protein kinase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
IDO1 indoleamine 2,3-dioxygenase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KDM5D lysine (K)-specific demethylase 5D
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
LMO4 LIM domain only 4
LRRC59 leucine rich repeat containing 59
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MMP3 matrix metallopeptidase 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
NOTCH2 notch 2
NRCAM neuronal cell adhesion molecule
PBK PDZ binding kinase
PCDH9 protocadherin 9
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTTG1 pituitary tumor-transforming 1
RNPS1 RNA binding protein S1, serine-rich domain
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPDL1 spindle apparatus coiled-coil protein 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM47 transmembrane protein 47
TPSAB1 tryptase alpha/beta 1
TPX2 TPX2, microtubule-associated
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
WIF1 WNT inhibitory factor 1
ZIC1 Zic family member 1