BRD-K94012289_OSI-027_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K94012289_OSI-027_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMOTL2 angiomotin like 2
ARMCX1 armadillo repeat containing, X-linked 1
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK14 cyclin-dependent kinase 14
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CTGF connective tissue growth factor
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
FLRT2 fibronectin leucine rich transmembrane protein 2
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GSN gelsolin
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPG2 heparan sulfate proteoglycan 2
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT19 keratin 19, type I
LAMB2 laminin, beta 2 (laminin S)
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LXN latexin
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MSLN mesothelin
N4BP2L1 NEDD4 binding protein 2-like 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NT5E 5'-nucleotidase, ecto (CD73)
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PRSS23 protease, serine, 23
PXDN peroxidasin
RBKS ribokinase
RPL36 ribosomal protein L36
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
S100P S100 calcium binding protein P
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SFRP4 secreted frizzled-related protein 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SSPN sarcospan
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM230 transmembrane protein 230
TPP1 tripeptidyl peptidase I
TSPAN31 tetraspanin 31
TXNIP thioredoxin interacting protein
ZFPM2 zinc finger protein, FOG family member 2
ZNF185 zinc finger protein 185 (LIM domain)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AMD1 adenosylmethionine decarboxylase 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
FABP1 fatty acid binding protein 1, liver
FADS1 fatty acid desaturase 1
FAM162A family with sequence similarity 162, member A
FASN fatty acid synthase
HAT1 histone acetyltransferase 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HK2 hexokinase 2
HP haptoglobin
HSPA14 heat shock 70kDa protein 14
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL13RA2 interleukin 13 receptor, alpha 2
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KIAA0226L KIAA0226-like
LRRC59 leucine rich repeat containing 59
MCM10 minichromosome maintenance complex component 10
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
PBK PDZ binding kinase
PFN2 profilin 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PRKCB protein kinase C, beta
RGS1 regulator of G-protein signaling 1
SATB2 SATB homeobox 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SFN stratifin
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SNX10 sorting nexin 10
SUB1 SUB1 homolog (S. cerevisiae)
TDO2 tryptophan 2,3-dioxygenase
TF transferrin
TFRC transferrin receptor
TIGAR TP53 induced glycolysis regulatory phosphatase
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
WIF1 WNT inhibitory factor 1